Evidence map›Paper›PMID 40484272›Full record

ArticleOsteoarthritis and cartilage2025

The relation of activity patterns with incident slow gait speed over 4 years in adults with knee osteoarthritis: Data from the Osteoarthritis Initiative.

Nurten Gizem Tore, Sydney Liles, David M Werner, Rebecca J Cleveland, Tom Videitch Bye, Yvonne Golightly, Jason T Jakiela, Daniel K White

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00080171 (Osteoarthritis Initiative), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00080171 completednot on this map

Osteoarthritis Initiative (OAI): A Knee Health Study

TypeobservationalSponsorNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Ran2004 to 2015Enrolled4,796ConditionsOsteoarthritis, Knee Osteoarthritis
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nurten Gizem ToreDepartment of Physiotherapy and Rehabilitation, Osmaniye Korkut Ata University, Osmaniye, Turkey. Electronic address: gizemtore@hotmail.com.
Sydney LilesDepartment of Physical Therapy, University of Delaware, Newark, United States of America. Electronic address: scliles@udel.edu.
David M WernerCollege of Allied Health Professions, University of Nebraska Medical Center, Omaha, United States of America. Electronic address: dwerner@unmc.edu.
Rebecca J ClevelandThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America. Electronic address: becki@unc.edu.
Tom Videitch ByeDepartment of Physical Therapy, University of Delaware, Newark, United States of America. Electronic address: tkbye@udel.edu.
Yvonne GolightlyCollege of Allied Health Professions, University of Nebraska Medical Center, Omaha, United States of America. Electronic address: ygolightly@unmc.edu.
Jason T JakielaWinston-Salem State University, Winston-Salem, NC, United States of America. Electronic address: jakielajt@wssu.edu.
Daniel K WhiteDepartment of Physical Therapy, University of Delaware, Newark, United States of America. Electronic address: dkw@udel.edu.

Funding

UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
NIAMS NIH HHS P30 AR072580NICHD NIH HHS T32 HD007490
6 · The paper itself

Abstract

objectiveThe purpose of this study was to describe activity patterns in adults with knee osteoarthritis (OA) and to examine the relation of patterns with incident slow gait speed over 4 years.

designUsing data from the Osteoarthritis Initiative, we included adults with or at high risk of knee OA who walked > 1.0 m/s during a 20-meter walk at baseline, i.e., did not have slow gait speed. To determine activity patterns, we reduced the dimensions of accelerometer data (ActiGraph GTM1) using a multidimensional Multilevel Functional Principal Components Analysis to calculate between-subject principal component (PC) scores. We estimated the association of the top and bottom tertiles' PC scores with incident slow gait speed over 4 years (risk ratios with 95% confidence intervals) referenced to the middle tertile, adjusting for potential confounders.

resultsWe identified four activity patterns (PCs): 1) high activity, 2) high evening activity, 3) high morning and evening activity, and 4) very high morning activity. Those whose daily activity patterns best matched with the pattern PC2 or PC4, were found to have 0.60 [0.37, 0.96] and 0.39 [0.22, 0.71] times the risk of developing slow gait speed, respectively; while those whose daily activity patterns least matched PC3, were found to have 1.77 [1.19, 2.62] times the risk.

conclusionsDaily activity patterns may be related to the development of slow gait speed in adults with or at risk for knee OA.

trial registrationNCT00080171.

Indexed as

ExerciseGaitOsteoarthritis, KneeWalking SpeedAccelerometryAgedFemaleHumansMaleMiddle AgedActivity patternsFunctional limitationKnee osteoarthritisSlow gait speed

Identifiers

PMID40484272
PMCPMC12353185

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.