Evidence map›Paper›PMID 40483789›Full record

Trial reportDrug and alcohol dependence2025

Portrayals of alcohol use disorder treatment outcomes and their effects on stigma: Population-based, randomized survey experiment in rural Uganda.

Yang Jae Lee, Jordan Jurinsky, Charles Baguma, Scholastic Ashaba, Bernard Kakuhikire, Elizabeth Betty Namara, Phionah Ahereza, Viola Kyokunda, Emily N Satinsky, Alexander C Tsai and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yang Jae LeeDepartment of Psychiatry, Yale University School of Medicine, 300 George St., New Haven, CT 06511, USA.
Jordan JurinskyEliot-Pearson Department of Child Study and Human Development, School of Arts and Sciences, Tufts University, 105 College Ave, Medford, MA 02155, USA.
Charles BagumaMbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Scholastic AshabaMbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Bernard KakuhikireMbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Elizabeth Betty NamaraMbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Phionah AherezaMbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Viola KyokundaMbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Emily N SatinskyDepartment of Psychology, Dornsife College of Letters, Arts & Sciences, University of Southern California, 501 Seeley G. Mudd Building, 3620 McClintock Ave, Los Angeles, CA 90089, USA; Center for Global Health, Massachusetts General Hospital, 125 Nashua St, Boston, MA 02114, USA.
Alexander C TsaiMbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda; Center for Global Health, Massachusetts General Hospital, 125 Nashua St, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Jessica M PerkinsDepartment of Human and Organizational Development, Peabody College of Education and Human Development, Vanderbilt University, 230 Appleton Place, Nashville, TN 37203, USA; Vanderbilt Institute of Global Health, Vanderbilt University Medical Center, 2525 West End Ave., Nashville, TN 37203, USA. Electronic address: jessica.m.perkins@vanderbilt.edu.

Funding

Perceived Norms About Alcohol Use and HIV/STI Prevention among Adolescents and Young Adults in Rural UgandaR01AA031936 · NIAAA · VANDERBILT UNIVERSITY · PI Jessica M Perkins · 2024 to 2026
$1.8M
Inflammation, Social Networks, and Depression in Rural UgandaR01MH125667 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI TSAI, ALEXANDER C · 2021 to 2023
$1.0M
Perceptions of Social Norms and Personal Propensity to Engage in HIV Testing: A Mixed Methods Study and Intervention in Rural UgandaK01MH115811 · NIMH · VANDERBILT UNIVERSITY · PI PERKINS, JESSICA M · 2018 to 2022
$857k
Mentoring in patient-oriented research on the U.S. substance use and HIV syndemicK24DA061696 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI ALEXANDER C TSAI · 2024 to 2026
$640k
NIAAA NIH HHS R01 AA031936NIDA NIH HHS K24 DA061696NIMH NIH HHS K01 MH115811NIMH NIH HHS R01 MH125667
6 · The paper itself

Abstract

introductionWe assessed the extent to which portrayals of AUD treatment effectiveness influenced multiple domains of stigma.

methodsThis cross-sectional, whole-population survey experiment was conducted with 1363 adults living in eight villages of southwestern Uganda in 2021-2022. Participants were randomly assigned to receive a vignette describing a typical man (control) or one of six vignette variants describing a man with untreated AUD, treated AUD, or other variations of treated or untreated AUD with differing outcomes. OUTCOMES: personal willingness to have the man marry into their family, belief that he is receiving divine punishment, and belief that he brings shame on his family. Participants also reported their perceptions about whether most people in their villages would hold those stigmatizing attitudes (i.e., perceived norms). We fitted multivariable Poisson regression models to estimate the effect of vignette assignment on personal beliefs and perceived norms.

resultsParticipants reported more stigmatizing personal beliefs across all AUD vignettes compared to control. Average marginal effects (AME) of assignment on the excess probability of stigmatizing personal beliefs ranged from 0.57 (95 % Confidence Interval CI=0.43-0.71) to 0.74 (CI=0.58-0.90) for unwillingness to have the man marry into their family, 0.66 (CI=0.53-0.80) to 0.81 (CI=0.67-0.95) for believing the man brings shame upon his family, and 0.29 (CI=0.20-0.38) to 0.36 (CI=0.27-0.46) for believing the man is receiving divine punishment. AMEs of vignette assignment on perceived norms were similar.

conclusionStigma toward men with AUD in rural Uganda was high regardless of AUD treatment effectiveness. Culturally-tailored stigma reduction interventions are needed.

Indexed as

AlcoholismSocial StigmaAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedRural PopulationSurveys and QuestionnairesTreatment OutcomeUgandaYoung AdultAlcohol consumptionDiscriminationEast AfricaPerceived normsRecoveryStigma

Identifiers

PMID40483789
PMCPMC12896135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.