Evidence map›Paper›PMID 40483726›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2025

Religiosity and the relationship between sexual trauma, alcohol use, and sleep quality: a moderated mediation model.

Paris B Wheeler, Chelsea D Mackey, Dezarie Moskal, Daniel J Brady, Katherine T Foster, Russell M Marks, Daniel L Dickerson, Deanna L Kelly, Melanie E Bennett, Daniel J O Roche

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02884908 phase3completednot on this map

Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2017 to 2022Enrolled57ConditionsPTSD, Alcohol Use DisorderArmsPregabalin plus BBCET, Placebo plus BBCET
NCT04210713 phase1completednot on this map

Characterization of Neuroimmune Dysfunction in Alcohol Use Disorder

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2020 to 2023Enrolled142ConditionsAlcohol Drinking, Alcohol-Related Disorders, Disease, InflammationArmsMinocycline, Sugar pill
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paris B WheelerDepartment of Psychology, University of Cincinnati, 2800 Clifton Avenue, Cincinnati, OH 45221, United States.
Chelsea D MackeyDepartment of Psychology, University of Washington, 3921 W Stevens Wy NE, Seattle, WA 98195, United States.
Dezarie MoskalVA Center for Integrated Healthcare, VA Western New York Healthcare System, 3495 Bailey Ave, Buffalo, NY 14215, United States.
Daniel J BradyDepartment of Psychology, Georgia State University, 140 Decatur St. SE, Atlanta, GA 30303, United States.
Katherine T FosterDepartment of Psychology, University of Washington, 3921 W Stevens Wy NE, Seattle, WA 98195, United States.ORCID 0000-0002-3561-6687
Russell M MarksDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 222 Richmond St, Providence, RI 02903, United States.
Daniel L DickersonIntegrated Substance Abuse Program, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, 885 Tiverton Drive, Los Angeles, CA 90095, United States.ORCID 0000-0001-6298-1519
Deanna L KellyMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, United States.
Melanie E BennettVA VISN 5 Mental Illness Research, Education and Clinical Center, Baltimore VA Medical Center, 10 N Greene St, Baltimore, MD 21201, United States.
Daniel J O RocheMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, United States.

Funding

Pharmacogenetic Treatment with Anti-Glutaminergic Agents for Comorbid PTSD & AUDR01AA024760 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI BENNETT, MELANIE E. · 2016 to 2020
$3.0M
Development of minocycline as a neuroimmune therapy for alcohol use disorderK01AA026005 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI ROCHE, DANIEL · 2017 to 2021
$925k
Department of Veterans Affairs or the United States governmentMaryland Industrial Partnerships Award 6623.20Maryland Industrial Partnerships Award F31AA030907Maryland Industrial Partnerships Award K01AA026005Maryland Industrial Partnerships Award R01AA024760Maryland Industrial Partnerships Award R25DA035163NIAAA NIH HHS K01 AA026005NIAAA NIH HHS R01 AA024760VA Office of Academic Affiliations
6 · The paper itself

Abstract

aimsSexual trauma is a known risk factor for both sleep problems and alcohol use. Understanding the complex comorbidity of these three concerns, including potential factors that may mitigate or exacerbate their relationship, is important to improve clinical care. Religiosity may serve as a protective factor for trauma-related outcomes, alcohol use, and sleep quality but also may exacerbate the relationship between sexual trauma and alcohol use. The current study examined whether alcohol use mediates the relationship between sexual trauma and sleep problems and whether religiosity moderates this indirect effect.

methodsData from 158 participants (Mage = 43.8, SD = 12.0; 32.3% cisgender women, 67.7% cisgender men) were drawn from eligibility screening assessments from three studies on alcohol use and/or post-traumatic stress disorder. Data were analyzed using mediation and moderated mediation analyses.

resultsAlcohol use did not mediate the relationship between sexual trauma and sleep quality (95% Boot CI [-0.07, 0.95]). However, when considering the role of religiosity, formal religious practices (but not God consciousness) moderated the indirect effect of sexual trauma on sleep quality through alcohol use (β = 0.89, 95% Boot CI [0.21, 1.92]). Specifically, the conditional indirect effect was significant for individuals with high levels of formal religious practices relative to individuals with low or average levels.

conclusionsSexual trauma was associated with poorer sleep quality due to heavier alcohol use when individuals had higher levels of formal religious practices. Findings have implications for assessment and treatment of comorbid trauma histories, alcohol use, and sleep problems.NCT02884908; NCT04210713.

Indexed as

Alcohol DrinkingReligion and PsychologySexual TraumaSleep QualitySleep Wake DisordersAdultFemaleHumansMaleMediation AnalysisMiddle Agedalcohol usereligiositysexual traumasleep

Identifiers

PMID40483726
PMCPMC13017220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.