Evidence map›Paper›PMID 40483587›Full record

ArticleThe FEBS journal2025

Insulin facilitates entry of calcium ions into human and murine erythrocytes via Piezo1: a newly identified mechanism with implications for type 2 diabetes.

Lennart Kuck, Tia A Griffith, Antony P McNamee, Jason N Peart, John H Wilson, Ajay Sharma, Lavanya A Sharma, Kai Robertson, Eugene F Du Toit, Michael J Simmonds

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mechanisms of Piezo1-Mediated Mechanotransduction in Thrombotic Diseases.International journal of molecular sciences · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lennart KuckBiorheology Research Laboratory, Griffith University, Gold Coast, Australia.ORCID https://orcid.org/0000-0003-2394-6547
Tia A GriffithSchool of Pharmacy and Medical Science, Griffith University, Gold Coast, Australia.
Antony P McNameeBiorheology Research Laboratory, Griffith University, Gold Coast, Australia.
Jason N PeartSchool of Pharmacy and Medical Science, Griffith University, Gold Coast, Australia.
John H WilsonSchool of Pharmacy and Medical Science, Griffith University, Gold Coast, Australia.
Ajay SharmaSchool of Medicine and Dentistry, Griffith University, Gold Coast, Australia.
Lavanya A SharmaSchool of Medicine and Dentistry, Griffith University, Gold Coast, Australia.
Kai RobertsonSchool of Pharmacy and Medical Science, Griffith University, Gold Coast, Australia.
Eugene F Du ToitSchool of Pharmacy and Medical Science, Griffith University, Gold Coast, Australia.
Michael J SimmondsBiorheology Research Laboratory, Griffith University, Gold Coast, Australia.

Funding

Australian Research Council DE240100236Australian Research Council DP230100556Department of Health and Aged Care, Australian Government RFRHPI000241Griffith University
6 · The paper itself

Abstract

Circulatory deficits are common and pathophysiologically relevant in type 2 diabetes mellitus (T2DM). Perturbed red blood cell (RBC) homeostasis and diminished nitric oxide (NO) availability contribute to endothelial dysfunction, a hallmark of cardiometabolic disorders; however, underlying pathophysiological mechanisms remain elusive. Here, we investigated RBC signaling pathways in a murine model of metabolic disease, focused on NO. T2DM-RBCs had elevated levels of cytosolic NO, intracellular calcium ions (Ca

Indexed as

CalciumDiabetes Mellitus, Type 2ErythrocytesInsulinIon ChannelsAnimalsHumansMaleMiceNitric OxideReactive Oxygen SpeciesCalciumInsulinIon ChannelsNitric OxidePIEZO1 protein, humanPiezo1 protein, mouseReactive Oxygen Speciescalcium signalingnitric oxidePiezo1red blood cellstype 2 diabetes

Identifiers

PMID40483587
PMCPMC12524981

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.