Evidence map›Paper›PMID 40483548›Full record

ArticleBiomarkers in medicine2025

Serum GP73, Nrf2, CHE in early pregnancy-related liver injury detection via RCS model.

Deng Huang, Yanjun Hu, Biwen Dong, Zhi Zheng, Hai Wang, Tingting Liao, Wenhan Wang, Xianjue Zheng, Zitong Xu, Shuqi Xia and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Deng HuangDepartment of Infectious Diseases, Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Yanjun HuDepartment of Gynecology and Obstetrics, Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Biwen DongDepartment of Reproductive Genetics, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University/The Third Affiliated Hospital of Shanghai University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Zhi ZhengDepartment of Gynecology and Obstetrics, Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Hai WangDepartment of Reproductive Genetics, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University/The Third Affiliated Hospital of Shanghai University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Tingting LiaoDepartment of Gynecology and Obstetrics, Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Wenhan WangWenzhou City Key Laboratory of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Wenzhou People's Hospital/Wenzhou Maternal and Child Healthcare Hospital, Wenzhou, Zhejiang, China.
Xianjue ZhengDepartment of Reproductive Genetics, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University/The Third Affiliated Hospital of Shanghai University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Zitong XuDepartment of Reproductive Genetics, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University/The Third Affiliated Hospital of Shanghai University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Shuqi XiaDepartment of Reproductive Genetics, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University/The Third Affiliated Hospital of Shanghai University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Xiaoqing LiWenzhou City Key Laboratory of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Wenzhou People's Hospital/Wenzhou Maternal and Child Healthcare Hospital, Wenzhou, Zhejiang, China.
Congcong SunWenzhou City Key Laboratory of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Wenzhou People's Hospital/Wenzhou Maternal and Child Healthcare Hospital, Wenzhou, Zhejiang, China.
Hongping ZhangDepartment of Gynecology and Obstetrics, Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.
Jiayong ZhengDepartment of Reproductive Genetics, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University/The Third Affiliated Hospital of Shanghai University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study assessed serum GP73, Nrf2, and CHE levels in pregnancy-associated liver injury and explored their nonlinear risk relationships using restricted cubic spline (RCS) models to establish diagnostic thresholds for early screening.

methodsConducted from December 2022 to December 2024, 105 pregnant women with liver injury (research group) and 187 healthy controls were retrospectively analyzed. Multivariate logistic regression, ROC curves, RCS models, and decision curve analysis (DCA) evaluated associations, predictive efficacy, dose-response relationships, and clinical utility of these biomarkers.

resultsElevated GP73 and Nrf2, multiple pregnancies, antipyretic/anti-infective medication use, and malnutrition were risk factors (

conclusionGP73, Nrf2, and CHE demonstrated nonlinear associations with pregnancy-related liver injury, particularly GP73. Combined measurement enhances clinical value for early prediction.

Indexed as

Liver DiseasesNF-E2-Related Factor 2Pregnancy ComplicationsAdultBiomarkersCase-Control StudiesFemaleHumansPregnancyRetrospective StudiesROC CurveBiomarkersNFE2L2 protein, humanNF-E2-Related Factor 2cholinesterasediagnostic efficacyearly screeningGolgi transmembrane glycoprotein 73Liver injury during pregnancynuclear factor-erythroid 2-related factor 2restricted cubic spline model

Identifiers

PMID40483548
PMCPMC12184170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.