ArticleIrish veterinary journal2025
Clinical benefits of early-stage autologous conditioned serum and injectable platelet-rich fibrin on healing superficial digital flexor tendonitis in donkeys.
Article in Irish veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injectable platelet-rich fibrin (I-PRF) has been explored for its regenerative potential, but its application in tendon healing remains unstudied. Autologous conditioned serum (ACS), commonly used in joint therapies, inhibits interleukin 1-mediated inflammation, though its role in tendon healing is not well established. This study aimed to evaluate the clinical benefits of I-PRF alone and in combination with ACS in tendon healing. Twenty-three donkeys with forelimb superficial digital flexor (SDF) tendonitis were examined at admission (T0) and randomly assigned to PRF/ACS treated group (n = 10), PRF group (n = 7), or included as a control group (n = 6). Among clinical parameters, tendon shape and weight-bearing scores at T150 were significantly improved (P < 0.001) in the PRF/ACS group compared to the control group. Regardless of the tendon cross-sectional area (T-CSA), all other ultrasonographic parameters showed significant improvement in the PRF/ACS group compared to the control group. T-CSA increased throughout the study in PRF group but significantly decreased at T150 in control and PRF/ACS groups. The combination therapy had a significant improvement in fiber alignment score (FAS) and T-CSA compared to PRF group. Early lesion resolution in PRF/ACS at T90 and later in PRF at T150 suggests superior healing in PRF/ACS group. Persistent increase in T-CSA in the PRF group indicates ongoing healing, while its reduction in the PRF/ACS groups reflects more progressed healing stages and superior outcomes. Conversely, the presence of hyperechoic dots and misaligned tendon fibers in the control group suggests inferior healing outcomes. Intralesional I-PRF combined with ACS significantly enhanced clinical and ultrasonographic healing characteristics in donkeys with SDF tendonitis.
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