ArticleWorld journal of surgical oncology2025
Dynamic changes in vasohibin and nitric oxide signaling following surgical resection of head and neck squamous cell carcinoma.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAngiogenesis is essential for tumor growth and metastasis, with various molecules, including vasohibin (VASH), nitric oxide (NO), and inducible nitric oxide synthase (iNOS), implicated in its regulation and potential prognostic value in oncology. However, their roles in modulating surgery-induced angiogenesis in head and neck squamous cell carcinoma (HNSCC) remain unclear. Therefore, the objective of the study was to assess the dynamic changes in VASH, NO, and iNOS levels in HNSCC patients undergoing surgical resection.
methodsWe prospectively enrolled patients with histology-proven HNSCC who underwent surgical resection of primary tumors at the medical center between May and November 2021. Non-cancer controls were recruited to compare baseline biomarker levels with those of HNSCC patients. We measured preoperative and postoperative levels of VASH1 and VASH2 in plasma and leukocytes using enzyme-linked immunosorbent assays and Western blotting, NO using nitrate/nitrite colorimetric assays, and iNOS phosphorylation levels in leukocyte membranes using Western blotting.
resultsPatients with HNSCC (n = 15) exhibited elevated baseline levels of VASH1, NO, and leukocyte-induced iNOS phosphorylation compared to non-cancer controls (n = 15). After tumor resection, plasma VASH1 levels were significantly downregulated (2233 ± 1464 pg·mL
conclusionsThis study demonstrated that dynamic changes in VASH and NO signaling following tumor resection could serve as a potential indicator of tumor angiogenesis. Our findings suggest that the overall activity of the VASH pathway in leukocytes was reduced after tumor removal, highlighting the potential of leukocyte physiology as a novel biomarker for cancer surveillance and control.
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