ArticleReproductive biology and endocrinology : RB&E2025
Global and regional trends in the burden of surgically confirmed endometriosis from 1990 to 2021.
Article in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of hormonal treatments for endometriosis on the reproductive microbiome: a systematic review.Frontiers in microbiology · 2026Pooled it
- Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management.MedComm · 2026Review
- Article
- Article
- Endometriosis-Associated Infertility in China: Epidemiological Trends, Future Projection, and Real-World Clinical Insights.International journal of women's health · 2026Article
- The Burden of Parkinson's Disease Based on the GBD 2021.International journal of public health · 2026Article
- Temporal changes in the burden of type 2 diabetes mellitus across the BRICS, 1990-2021: a comprehensive analysis for the global burden of disease study 2021.BMC public health · 2025Article
- Graptophyllum pictum (Acanthaceae) relieves some hallmarks of endometriosis in an experimental model in Wistar rats.Reproduction & fertility · 2025Article
- Global burden of endometriosis from 1990 to 2021 and projections to 2050: a comprehensive analysis based on the global burden of disease study 2021.Frontiers in global women's health · 2025Article
- Global, regional, and national burden of ischemic heart disease attributable to lead exposure, 1990-2021: decomposition, frontier, and projection analysis.Frontiers in public health · 2025Article
- Endometriosis burden and trends among women of childbearing age from 1990 to 2021.Frontiers in endocrinology · 2025Article
- Article
- Endometriosis-related infertility in China: analysis of the global burden of disease study 2021.Frontiers in public health · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundendometriosis as a common gynecologic finding significantly affects the quality of life of many women. An accurate understanding of the epidemiological characteristics of endometriosis is essential for disease control and prevention. We aimed to use the latest data from the Global Burden of Disease (GBD) 2021 to comprehensively analyze the various epidemiological indicators of surgically confirmed endometriosis and their changing trends to better measure the disease burden and help improve health management.
methodsWe delineated incidence, prevalence, and years lived with disability (YLDs) of surgically confirmed endometriosis at the global, regional, and national levels. The estimated annual percentage change (EAPC) was calculated to assess temporal trends in the age-standardized rate (ASR). In addition, we used joinpoint regression models to describe local trends in these indicators, assessed the correlation between disease burden and Socio-demographic index (SDI) levels, and used decomposition analysis to quantitatively analyze the driving factors leading to changes in disease burden.
resultsGlobally, the age-standardized rate of incidence, prevalence, and YLDs of surgically confirmed endometriosis all showed a decreasing trend from 1990 to 2021. The burden of surgically confirmed endometriosis is mainly concentrated in women aged 20-30 years and declines with increasing SDI levels. The results of the decomposition analysis indicated that population growth is the main driving factor for the upward in the number of incidence, prevalence, and YLDs cases of endometriosis worldwide.
conclusionsThe overall burden of endometriosis has decreased globally from 1990 to 2021, but there are regional disparities. Managing this condition remains a major challenge, and more refined policies and interventions are needed to effectively address the burden of endometriosis.
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