ArticleCommunications chemistry2025
Hydrazone-based photocages for precise sub-organelle visualization and drug release.
Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- DNA-Based Boolean Logic Gates for Molecular Computation and Biosensing: A Critical Review.Molecular biotechnology · 2026Review
- Design, Synthesis, Bioactivity, and Docking Studies of Isatin-Hydrazone Derivatives as Potential CDK-2 Inhibitors.Anti-cancer agents in medicinal chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Photocages are widely investigated for their bioimaging, controlled drug release, and cellular process modulation. Developing universal photoactive units can significantly expand the structural diversity of photocages. Herein, we developed a class of photoactive units based on the classic aldehyde-hydrazone moiety by conjugating several fluorescent aldehydes with various substituted phenylhydrazines. The resulting hydrazone-based photocages degraded upon exposure to light (365-450 nm), releasing fluorescent aldehydes. Fluorescent enhancements, redshifts or blueshifts were clearly observed during uncaging. For bio-application, morpholine-hydrazone based hybrid BW3MP, staurosporine-derived hybrids BW3STS and FY4STS were constructed. They exhibited high release efficiencies of MP (75.5%, BW3MP) and STSA (65.3%, BW3STS), respectively. BW3MP co-localized with a lysosome dye, exhibiting a Pearson correlation coefficient of 0.94. The biological activity of BW3STS was unmasked under irradiation, with a 4-fold increase in IC
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.