Evidence map›Paper›PMID 40483350›Full record

ArticleNPJ biofilms and microbiomes2025

The role of gut microbiota-gonadal axis in ovary activation of Asian honey bee (Apis cerana) queens.

Chonghui Zhao, Yehua Peng, Wenfeng Li, Muhammad Fahad Raza, Wenbo Wang, Yi Zhang, Yanping Chen, Jun Guo, Shaokang Huang, Richou Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chonghui Zhao *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Yehua Peng *Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China.
Wenfeng Li *Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China. wfli.bees@giz.gd.cn.
Muhammad Fahad RazaGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China.
Wenbo WangGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China.
Yi ZhangSchool of Chinese Medicinal Resource, Guangdong Pharmaceutical University, Yunfu, China.
Yanping ChenUSDA-ARS Bee Research Laboratory, Beltsville, MD, USA.
Jun GuoFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China. guojun0591@126.com.
Shaokang HuangCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou, China. skhuang@fafu.edu.cn.
Richou HanGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China. hanrc@giz.gd.cn.

Funding

GDAS' Project of Science and Technology Development 2022GDASZH-2022010102Guangzhou Science and Technology Plan Project 202103000009National Natural Science Foundation of China 32000347National Natural Science Foundation of China 32260863Seed Industry Revitalization Action of the Department of Agriculture and Rural Affairs of Guangdong Province 2024-XPY-00-014Talent Project of Guangdong Institute of Applied Biological Resources GIABR-gjrc201702
6 · The paper itself

Abstract

The gut microbiota-gonadal axis is increasingly recognized, but its reproductive roles remain unclear. Here, we used the Asian honey bee Apis cerana queens as a model to investigate the role of the gut microbiota-gonadal axis on ovary activation. By artificially caging and releasing the mated queens for a short or long period and monitoring the morphological changes of their ovaries, we confirmed that the activation and suppression of the queen ovary could be switched quickly. We found that the ovary weight was positively correlated with the body weight. 16S rRNA sequencing showed ovarian deactivation reduced gut Lactobacillus abundance. Untargeted metabolomics identified purine metabolism as the dominant ovarian pathway, while correlation analyses implicated Lactobacillus in modulating ovarian morphology through purine signaling. This study elucidates microbiota-gonadal crosstalk governing reproduction, providing mechanistic insights with translational potential for reproductive health management.

Indexed as

Gastrointestinal MicrobiomeOvaryAnimalsBacteriaBeesFemaleLactobacillusMetabolomicsReproductionRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID40483350
PMCPMC12145443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.