Enhanced solubility and bioavailability of coenzyme Q10 via co-amorphous system using stevioside.

Yingting Luo, Yuxin Li, Xuening Song, Yuzhuo Wang, Simiao Liu, Fazheng Ren, Hao Zhang

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Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Yingting LuoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Yuxin LiCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Xuening SongCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Yuzhuo WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Simiao LiuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Fazheng RenCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Hao ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. zhanghaocau@cau.edu.cn.

Funding

National Key Research and Development Program of China No. 2022YFF1100402

6 · The paper itself

Abstract

Coenzyme Q10 (CoQ10) plays a vital role in aerobic respiration and cardiovascular diseases; however, its application is limited owing to poor water solubility. In this study, equimolar CoQ10 and stevioside (STE) formed a co-amorphous (CM) system by lyophilization, and its solubility was approximately 63 times higher than that of CoQ10. Through crystal, thermodynamic, and morphological characterization of the formula, the formation of the CM system was confirmed. The intermolecular interactions were investigated by spectroscopies. The relationship of 8 intermolecular interaction sites between the two was confirmed via molecular dynamics simulation, firmly indicating the strong intermolecular forces. Further, CM products remained stable even under accelerated storage conditions, equivalent to 1 year at room temperature. Meanwhile, the area under curve (AUC) values increased by 5 times in the in vivo bioavailability study. In conclusion, the CoQ10 was transformed into an amorphous structure by initially employing STE through intermolecular interactions to enhance solubility.

Identifiers

PMID40483335

DOI10.1038/s41538-025-00465-0

PMCPMC12145421

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.