ArticleCell biology and toxicology2025
Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer.
Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- What Is-and What Is Not-Immunogenic Cell Death? Functional Definitions, Experimental Standards, and Common Pitfalls.International journal of molecular sciences · 2026Review
- Annexin A1 triggers autophagy to orchestrate radioiodine resistance in thyroid cancer via upregulating HMGB1.Cancer cell international · 2026Article
- Crosstalk between the microbiome and immune microenvironment in the pathogenesis and treatment of thyroid carcinoma: a narrative review.Frontiers in immunology · 2026Review
- Thyroid Cancer in the Modern Era: From Molecular Landscape and Multimodal Diagnostics to Integrative Traditional Chinese Medicine-A Comprehensive Review.Cancer management and research · 2026Review
- Advances in immunotherapy for thyroid malignancies: from molecular targets to clinical outcomes.Frontiers in medicine · 2026Review
- FPR1-dependent Pro-inflammatory Ccl4Respiratory research · 2025Article
- Personalised immunotherapy strategies informed by single cell profiling in thyroid cancer: a mini review.Frontiers in immunology · 2025Review
- Article
- Integrated multi-omics analysis of single-cell and spatial transcriptomics reveals distinct hpv-associated immune microenvironment features and prognostic signatures in cervical cancer.Frontiers in immunology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Thyroid cancer (THCA) is profoundly influenced by its immune microenvironment, with dendritic cells (DCs) serving as key mediators of tumor-immune interactions. This study leveraged single-cell RNA sequencing and transcriptome RNA sequencing to analyze DC populations in THCA tissues. The results revealed significant disparities in DC distribution and function, with formyl peptide receptor 1 (FPR1) emerging as a crucial factor associated with patient prognosis. Meta-analysis further validated the differential expression of FPR1, reinforcing its significance in THCA progression. Investigations into the TME highlighted the relationship between FPR1 and DC maturation and activation, elucidating the mechanistic basis for immune regulation. Experimental validation confirmed that Annexin A1 (ANXA1) interacts with FPR1 in DCs, promoting tumor progression through immune modulation. These findings advance the understanding of THCA immune mechanisms and underscore the potential of targeting the ANXA1-FPR1 axis as a novel approach for immunotherapy in THCA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.