Evidence map›Paper›PMID 40483271›Full record

ArticleCommunications biology2025

Substitution of polysorbates by plant-based emulsifiers: impact on vitamin D bioavailability and gut health in mice.

Ángela Bravo-Núñez, Angélique Berthomé, Charlotte Sabran, Donato Vairo, Jean-Charles Martin, Katherine Alvarado-Ramos, Benoit Chassaing, Julie Tomas, Emmanuelle Reboul

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Vitamin DMolecular nutrition & food research · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ángela Bravo-NúñezAix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France. angela.bravo-nunez@univ-amu.fr.ORCID http://orcid.org/0000-0001-5983-5334
Angélique BerthoméAix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France.
Charlotte SabranAix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France.
Donato VairoAix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France.ORCID http://orcid.org/0000-0002-8771-6524
Jean-Charles MartinAix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France.
Katherine Alvarado-RamosAix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France.
Benoit ChassaingMicrobiome-Host Interactions, Institut Pasteur, Université Paris Cité INSERM U1306, Paris, France.
Julie TomasAix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.ORCID http://orcid.org/0000-0001-9389-0273
Emmanuelle ReboulAix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France. Emmanuelle.Reboul@univ-amu.fr.ORCID http://orcid.org/0000-0002-4576-1992

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-18-EURE-0009Agence Nationale de la Recherche (French National Research Agency) ANR-20-PAMR-0002Agence Nationale de la Recherche (French National Research Agency) ANR-21-CE15-0042-01EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-2018-StG-804135EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-2024-CoG-101170920
6 · The paper itself

Abstract

Although long considered safe, recent data have shown that emulsifiers such as polysorbates promoted intestinal inflammation and were associated with increased risks of developing chronic pathologies. We evaluated the potential of plant-based emulsifiers (pea protein isolate, PPI, and corn arabinoxylans, CAX) as alternatives to Polysorbate 80 (Tween 80, T80). Combining PPI and CAX led to a similar vitamin D

Indexed as

Emulsifying AgentsPolysorbatesVitamin DAnimalsBiological AvailabilityFemaleGastrointestinal MicrobiomeMaleMiceEmulsifying AgentsPolysorbatesVitamin D

Identifiers

PMID40483271
PMCPMC12145454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.