Evidence map›Paper›PMID 40483181›Full record

SynthesisBritish journal of anaesthesia2025

Perioperative oxygen therapy: an overview of systematic reviews and meta-analyses.

Adel Elfeky, Yen-Fu Chen, Amy Grove, Keith Couper, Rachel Court, Sara Tomassini, Anna Wilson, Amy Hooper, Alexandra Buckle, Sharvari Vadeyar and 3 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07525661 (Effects of Perioperative Hyperoxia Versus Normoxia on Pulmonary, Endothelial, and Inflammatory Biomarkers in Elective Laparoscopic Lower Abdominal Surgery), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07525661 nacompletednot on this map

Effects of Perioperative Hyperoxia Versus Normoxia on Pulmonary, Endothelial, and Inflammatory Biomarkers in Elective Laparoscopic Lower Abdominal Surgery

TypeinterventionalSponsorIstanbul UniversityRan2017 to 2019Enrolled76ConditionsHyperoxia, Perioperative Care, Oxidative Stress, Endothelial Glycocalyx InjuryArmsPerioperative Oxygen Strategy - Normoxia, Perioperative Oxygen Strategy-Hyperoxia
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adel ElfekyWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Yen-Fu ChenWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Amy GroveWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Keith CouperWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Rachel CourtWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Sara TomassiniWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Anna WilsonWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Amy HooperUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Alexandra BuckleUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Sharvari VadeyarUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Marion ThompsonUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Olalekan UthmanWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Joyce YeungWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Electronic address: j.yeung.4@warwick.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative oxygen is routinely used, but evidence of its clinical impact remains inconsistent, leading to variable practice. The aim of this work was to provide a comprehensive overview of the effectiveness of perioperative oxygen therapy strategies.

methodsWe searched multiple databases for systematic reviews comparing perioperative oxygen strategies. Two reviewers independently extracted data. The co-primary outcomes were surgical site infection (SSI) and mortality. We classified systematic reviews with the largest number of trials as anchoring reviews. We updated anchoring reviews with data from more recent RCTs. We assessed the risk of bias of the anchoring reviews using the ROBIS tool, updated meta-analyses and subgroup analyses, and undertook exploratory meta-regression. We assessed the certainty in evidence using GRADE framework and conducted trial sequential analysis.

resultsFifty-nine systematic reviews met the inclusion criteria, from which five anchoring reviews were selected. Perioperative high fraction of inspired oxygen (Fio

conclusionsWe did not find evidence to support routine use of high inspired oxygen to reduce surgical site infection and improve patient outcomes. A small reduction in surgical site infection associated with high Fio SYSTEMATIC REVIEW PROTOCOL: PROSPERO CRD42021272361.

Indexed as

Oxygen Inhalation TherapyPerioperative CareHumansMeta-Analysis as TopicOxygenSurgical Wound InfectionSystematic Reviews as TopicOxygenmeta-analysisoverview reviewoxygen therapysurgerysurgical wound infectionumbrella review

Identifiers

PMID40483181
PMCPMC12597348

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.