Evidence map›Paper›PMID 40482731›Full record

ArticleNeurobiology of disease2025

Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy.

Nicholas Denomme, Samantha L Hodges, Luis Lopez-Santiago, Yukun Yuan, Julie M Ziobro, Joe Minton, Chunling Chen, Yan Chen, Jacob M Hull, James Offord and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicholas DenommeDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Samantha L HodgesDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Luis Lopez-SantiagoDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yukun YuanDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Julie M ZiobroDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Joe MintonDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Chunling ChenDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yan ChenDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jacob M HullDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
James OffordDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Alan V SmrckaDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Lori L IsomDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: lisom@umich.edu.

Funding

Understanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8M
Role of SCN1B in Inherited EpilepsyR37NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2017 to 2023
$4.8M
Role of Sodium Channel SCN1B in Inherited EpilepsyR01NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2011 to 2014
$1.6M
Mechanisms of PCDH19-clustering epilepsyK08NS124937 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie M Ziobro · 2023 to 2026
$976k
Role of Sodium Channel SCN1B in Inherited EpilepsyR56NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2015 to 2015
$532k
NIGMS NIH HHS R35 GM127303NINDS NIH HHS K08 NS124937NINDS NIH HHS R01 NS076752NINDS NIH HHS R37 NS076752NINDS NIH HHS R56 NS076752
6 · The paper itself

Abstract

Guanine nucleotide-binding protein Gβγ subunits are ubiquitous signaling molecules that interact with numerous effector proteins in neurons, including voltage-gated sodium, calcium, and potassium channels. We show that Gβγ subunits associate with voltage-gated sodium channels (Na

Indexed as

Brain DiseasesGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsVoltage-Gated Sodium ChannelsAnimalsBrainHEK293 CellsHumansMaleMiceMice, Inbred C57BLMice, TransgenicNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelG-protein Beta gammaGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelVoltage-Gated Sodium ChannelsDevelopmental and epileptic encephalopathyGNB1G-proteinVoltage-gated sodium channel

Identifiers

PMID40482731
PMCPMC12531703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.