ArticleDevelopmental biology2025
Zebrafish sall1a and sall4 contribute to body elongation.
Article in Developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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6 authors.
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Abstract
Vertebrate embryos elongate the body after gastrulation. Unlike in mice, which elongate both the trunk and tail after gastrulation, zebrafish embryos complete development of the trunk by the end of gastrulation, followed by tail elongation by proliferation of posteriorly located progenitors. Previous studies have shown that the transcription factors SALL1 and SALL4 redundantly regulate tail elongation in mouse embryos. To test whether sall1a and sall4 also regulate tail elongation in zebrafish, we generated zebrafish mutants for these genes. By 24 h post-fertilization, sall4 mutant embryos developed normally but exhibited changes in gene expression at the posterior end of the body. sall1a mutants also developed normally by 24 h post-fertilization. However, embryos mutant for both sall1a and sall4 showed a slight but significant reduction in body length compared to wild-type embryos. Our results support a role for sall1a and sall4 in tail elongation in zebrafish, though their contribution appears smaller than that observed in mouse embryos.
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