Evidence map›Paper›PMID 40482641›Full record

ArticleAmerican journal of human genetics2025

Complexity within simplicity: Exploring the multifactorial nature of sickle cell disease.

Athena Starlard-Davenport

Abstract read
In one paragraph

Article in American journal of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Athena Starlard-DavenportUniversity of Tennessee Health Science Center, College of Medicine, Department of Genetics, Genomics and Informatics, Memphis, TN 38163, USA. Electronic address: astarlar@uthsc.edu.

Funding

MicroRNA-based epigenetic approach to induce fetal hemoglobinR01HL144641 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI STARLARD-DAVENPORT, ATHENA · 2020 to 2022
$928k
NHLBI NIH HHS R01 HL144641
6 · The paper itself

Abstract

Sickle cell disease, though monogenic, exhibits complex clinical variability driven by genetic, epigenetic, and environmental factors. This commentary highlights advances in precision therapies and underscores the urgent need for equitable access, global collaboration, and personalized approaches to address the significant health disparities impacting individuals with sickle cell disease worldwide.

Indexed as

Anemia, Sickle CellMultifactorial InheritanceHumans

Identifiers

PMID40482641
PMCPMC12256871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.