ArticlePhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2025
Iodine quantification performance with deep silicon-based Photon-Counting CT: A virtual imaging trial study.
Article in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Optimizing energy settings in CdTe, CZT, and Si photon-counting CT for material separation and detection.Physics in medicine and biology · 2026Article
- Development of a customizable model for spectral photon-counting detector CT.Medical physics · 2025Article
- Liver fat quantification using deep silicon photon-counting CT: anRadiology advances · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
purposeThis study investigates the imaging performance of a deep silicon-based photon-counting CT (Si-PCCT) in quantifying iodine contrast through a virtual imaging trial (VIT).
methodsWe developed a VIT framework using Si-PCCT simulator and benchmarked it against a prototype using an ACR phantom for assessing spatial resolution and noise characteristics, and a geometric phantom for iodine quantification. We imaged geometrical phantoms (20 - 40 cm) with iodine concentrations ranging from 1 to 19.7 mg/ml and XCAT human models with iodine contrast at BMI of 19 to 38 kg/m
resultsThe Si-PCCT simulator closely matched with the prototype, with differences within 3 % in MTF (f
conclusionThis study shows the promising clinical utility of Si-PCCT for accurate iodine quantification under clinically relevant imaging conditions.
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