Evidence map›Paper›PMID 40482517›Full record

ArticleDrug and alcohol dependence2025

HEALing Communities Study: Data measures for supporting a community-based intervention to reduce opioid overdose deaths.

Svetla Slavova, Jennifer Villani, Daniel J Feaster, Austin Booth, JaNae L Holloway, Peter J Rock, Lindsey R Hammerslag, Aimee Mack, Charles E Knott, John V McCarthy and 7 more

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Svetla SlavovaDepartment of Biostatistics, University of Kentucky, Healthy Kentucky Research Building, Suite 260, 760 Press Avenue, Lexington, KY 40536, USA. Electronic address: ssslav2@email.uky.edu.
Jennifer VillaniNational Institutes of Health, National Institute on Drug Abuse, 3WFN, MSC 6025, 301 North Stonestreet Avenue, Bethesda, MD 20892, USA. Electronic address: jennifer.villani@nih.gov.
Daniel J FeasterDepartment of Public Health Sciences, University of Miami Miller School of Medicine, 1425 NW 10th Avenue, Room 1059, Miami, FL 33136, USA. Electronic address: dfeaster@med.miami.edu.
Austin BoothSocial, Statistical and Environment Sciences, Health Practice Area, RTI International, 6110 Executive Blvd, Suite 900, Rockville, MD 20852, USA. Electronic address: abooth@rti.org.
JaNae L HollowayCenter for Clinical Research, Analytics Practice Area, RTI International, 3040 E Cornwallis Rd, Research Triangle Park, NC 27709, USA. Electronic address: jlholloway@rti.org.
Peter J RockInstitute for Biomedical Informatics, University of Kentucky, Healthy Kentucky Research Building, Suite 260, 760 Press Avenue, Lexington, KY 40536, USA. Electronic address: peter.rock@uky.edu.
Lindsey R HammerslagDivision for Biomedical Informatics, College of Medicine, University of Kentucky, Healthy Kentucky Research Building, Suite 260, 760 Press Avenue, Lexington, KY 40536, USA. Electronic address: l.hammerslag@uky.edu.
Aimee MackThe Ohio Colleges of Medicine Government Resource Center, The Ohio State University Wexner Medical Center, 150 Pressey Hall, 1070 Carmack Road, Columbus, OH 43210, USA. Electronic address: Aimee.mack@osumc.edu.
Charles E KnottSocial, Statistical and Environment Sciences, Data Practice Area, RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: cknott@rti.org.
John V McCarthySocial, Statistical and Environment Sciences, Analytics Practice Area, RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: jmccarthy@rti.org.
Jeffery TalbertDivision of Biomedical Informatics, University of Kentucky College of Medicine, 267 Healthy Kentucky Research Building, 760 Press Avenue, Lexington, KY 40536, USA. Electronic address: jeff.talbert@uky.edu.
Marc R LaRochelleClinical Addiction Research and Education Unit, Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine and Boston Medical Center, 801 Massachusetts Avenue, 2nd Floor, Boston, MA 02118, USA. Electronic address: marc.larochelle@bmc.org.
Bridget FreisthlerOhio State University College of Social Work, 1947 N. College Road, Columbus, OH 43210, USA. Electronic address: freisthler.19@osu.edu.
Brent J GibbonsSocial, Statistical and Environment Sciences, Health Practice Area, RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: bgibbons@rti.org.
Gregory PattsCenter for Health Data Science (CHDS), Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA. Electronic address: gpatts@bu.edu.
Matthew J BullardCenter for Health Data Science (CHDS), Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA. Electronic address: mbullard@bu.edu.
Sharon L WalshDepartment of Behavioral Science, University of Kentucky, 109 Medical Behavioral Science Building, Lexington, KY 40536, USA; Center on Drug and Alcohol Research, University of Kentucky, College of Medicine, 845 Angliana Avenue, Lexington, KY 40508, USA. Electronic address: sharon.walsh@uky.edu.

Funding

MassHEAL - Reducing overdose deaths by 40% (2019-2023)UM1DA049412 · NIDA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2019 to 2023
$82.9M
Kentucky CAN HEAL (Communities and Networks Helping End Addiction Long-term)UM1DA049406 · NIDA · UNIVERSITY OF KENTUCKY · PI WALSH, SHARON L. · 2019 to 2022
$81.7M
CHASE: An Innovative County-Level Public Health Response to the Opioid Epidemic in New York StateUM1DA049415 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI EL-BASSEL, NABILA, GILBERT, LOUISA · 2019 to 2023
$77.3M
Optimizing HEALing in Ohio Communities (OHiO)-Health Equity SupplementUM1DA049417 · NIDA · OHIO STATE UNIVERSITY · PI FREISTHLER, BRIDGET J, WINHUSEN, T JOHN · 2019 to 2023
$66.3M
HEALing Communities Study Health Equity ResearchUM1DA049394 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI GLASGOW, LASHAWN, KNOTT, CHARLES · 2019 to 2023
$40.6M
NIDA NIH HHS UM1 DA049394NIDA NIH HHS UM1 DA049406NIDA NIH HHS UM1 DA049412NIDA NIH HHS UM1 DA049415NIDA NIH HHS UM1 DA049417
6 · The paper itself

Abstract

introductionThe HEALing Communities Study (HCS) tested a community-based intervention in 67 communities across Kentucky, Massachusetts, New York, and Ohio to reduce opioid overdose deaths. This paper introduces the HCS measures for monitoring the intervention uptake, reports crude rates for benchmarking, and highlights the importance of interpreting jurisdictional trends in the context of state policies.

methodsWe present technical specifications for the HCS measures and the common data model. Crude rates for the evaluation period (July 2021- June 2022) are reported by state and study arm (intervention/Wave 1 or wait-listed/Wave 2 communities), along with longitudinal trends from 2017 to 2023. Year 2023 serves as a post-intervention period for Wave 1 communities and an intervention year for Wave 2 communities.

resultsAfter unprecedented increases in 2020-2021, the HCS crude opioid overdose death rates declined in 2023, but remained higher than the 2019 pre-pandemic rates. Opioid overdose death rates exceeded 100/100,000 adults among Non-Hispanic Black individuals in several states. In response to the rapid increase in opioid overdose deaths in Kentucky, the HCS team expanded the naloxone distribution in Kentucky intervention communities, reaching a 10-fold increase in Quarter 3 of 2021 (1498.2 units/100,000 residents). The methadone medication for opioid use disorder (MOUD) treatment rate for Medicaid enrollees with opioid use disorder during the evaluation period was highest in Massachusetts intervention communities (274/1000), while the buprenorphine MOUD treatment rate was highest in Kentucky (441/1000).

conclusionsThe HCS measures support comprehensive planning and evaluation of population-level opioid overdose prevention interventions and policies.

Indexed as

Drug OverdoseOpiate OverdoseOpioid-Related DisordersAdultFemaleHumansKentuckyMaleMassachusettsMiddle AgedNaloxoneNarcotic AntagonistsNew YorkOhioUnited StatesNaloxoneNarcotic AntagonistsBuprenorphineHEALing Communities Study (HCS)Medication for opioid use disorder (MOUD)MethadoneNaloxoneOpioid overdose

Identifiers

PMID40482517
PMCPMC12238825

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.