Evidence map›Paper›PMID 40482194›Full record

ArticleAging2025

Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression.

Joseph Rupert, Zhanguo Gao, Yongmei Yu, Mikhail G Kolonin

Abstract read
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joseph RupertThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
Zhanguo GaoThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
Yongmei YuThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
Mikhail G KoloninThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.

Funding

Metabolic consequences of adipocyte progenitor replicative senescence: mechanism and interventionR01DK125922 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOLONIN, MIKHAIL G, MAHAN, KRISTIN ECKEL · 2021 to 2024
$1.5M
NIDDK NIH HHS R01 DK125922
6 · The paper itself

Abstract

The effects of cell senescence in individual cell populations of the tumor microenvironment (TME) on cancer progression remain unclear. Here, we investigated the effects of cell senescence caused by inactivation of the catalytic subunit of telomerase (Tert) in distinct TME components. We generated genetic

Indexed as

Cellular SenescenceEndothelial CellsMyeloid CellsTelomeraseAnimalsDisease ProgressionFemaleHumansMaleMiceMice, KnockoutPancreatic NeoplasmsProstatic NeoplasmsTumor MicroenvironmentTelomeraseTert protein, mouseendothelialmesenchymalmyeloidsenescencetelomerase

Identifiers

PMID40482194
PMCPMC12245194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.