ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2025
Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis.
Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort.Communications medicine · 2026Article
- Phenotypes of Preterm Birth: A Retrospective Cohort Study from a Tertiary Romanian Centre as a Framework for Future Genomic and Proteomic Research.Journal of clinical medicine · 2026Article
- Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveTo investigate the alterations in lipid metabolites and circulating inflammatory factors associated with preterm birth, elucidate their interactions, and uncover the underlying pathophysiologic mechanisms. By identifying potential predictive biomarkers and informing the development of effective therapeutic interventions, this research seeks to improve maternal and neonatal health outcomes.
methodsThis study included 179 lipid species (n = 7174) and 91 circulating inflammatory factors (n = 14 824) as exposure variables, with preterm birth data from the FinnGen database (n = 186 212) serving as the outcome variable. We applied a two-sample Mendelian randomization approach and mediation analysis techniques to identify specific biomarkers causally associated with preterm birth and to investigate the relationships between them from a genetic perspective.
resultsIn this study, we identified 11 lipid metabolites that show a significant causal association with preterm birth, of which eight are positively correlated and three are negatively correlated. Additionally, we identified 18 circulating inflammatory factors with a significant causal relationship to preterm birth, with 10 showing a negative correlation and eight a positive correlation. Adenosine deaminase (ADA) served as a crucial protective factor against preterm birth (P = 0.006, 95% confidence interval [CI] 0.90-0.98) and mediated the causal relationships between various lipid metabolites and preterm birth.
conclusionThis Mendelian randomization study identifies dysregulated lipid metabolism and inflammatory pathways influencing preterm birth. It identifies dysregulated lipid metabolism and inflammatory pathways influencing preterm birth. ADA is a significant protective factor against preterm birth. Specific phosphatidylcholine subtypes exert their protective effects against preterm birth through an ADA-dependent pathway. The mediation effect was -0.005 (95% CI -0.01 to -0.001). This finding not only deepens our understanding of the inflammatory origins of preterm birth but also provides direct evidence for the development of precision prevention strategies based on the regulation of the lipid-inflammation axis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.