ArticleMolecular biology reports2025
Neolitsea sericea attenuates oxidative stress-induced cell death in human neuroblastoma SH-SY5Y cells via MAPK and NF-κB pathway Inhibition.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Self-propelled nanozyme motors for targeted therapy of radiation cystitis by disrupting the inflammation-cfDNA vicious cycle.Journal of nanobiotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress is a key contributor to the pathological mechanisms that underpin various neurodegenerative diseases. Hydrogen peroxide (H METHODS AND
resultsSH-SY5Y cells were pretreated with NSE before exposure to hydrogen peroxide (H₂O₂), and cell viability was assessed using a WST-1 assay. Western blotting was used to analyze key proteins involved in apoptosis and inflammatory signaling. NSE significantly decreased hydrogen peroxide (H₂O₂)-induced cytotoxicity in SH-SY5Y cells. NSE inhibited caspase-3 activation, regulated apoptosis-related protein expression by upregulating Bcl-2 and downregulating Bax, and suppressed the activation of mitogen-activated protein kinases. NSE also attenuated the nuclear translocation of NFκB transcription factors, indicating an anti-inflammatory effect.
conclusionsThese findings show that NSE effectively mitigates oxidative damage in neuronal cells, highlighting its potential as a complementary or alternative therapeutic method for the prevention and management of neurodegenerative diseases.
Indexed as
Identifiers
40481995What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.