ReviewMolecular diversity2025
Unraveling the role of deuterium in cancer: mechanisms, detection techniques, and therapeutic potential.
Review in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Deuterium Concentration as a Dual Regulator: Depletion and Enrichment Elicit Divergent Transcriptional Responses in A549 Lung Adenocarcinoma Cells.International journal of molecular sciences · 2026Article
- Gene Expression Patterns in Lung Adenocarcinoma Cells in Response to Changes in Deuterium Concentration.International journal of molecular sciences · 2025Article
- Photocatalyst-free photochemical deuteration via H/D exchange with DNature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Deuterium, an element recognized for its close association with cancer, is involved in every stage from tumorigenesis and basic research methodologies to clinical diagnosis, therapeutic interventions, and drug development. Several significant findings have emerged in this field. This review explores the potential mechanisms by which deuterons influence cancer initiation and progression in the form of deuterium oxide including deuterium-enriched water (DEW) and deuterium-depleted water (DDW). Besides, deuterium, a stable hydrogen isotope with unique physicochemical properties, also plays a pivotal role in detection and drug discovery. We delve into the importance of deuterium-labeled compound detection techniques-such as hydrogen-deuterium exchange mass spectrometry, deuterium metabolism imaging, Raman deuterium isotope probe techniques, and the applications of AI in Deuterium-related detection techniques-in identifying tumor biomarkers, elucidating metabolic pathways, and validating drug targets. The advantages and limitations of these techniques, particularly in the realm of imaging, are discussed. Deuterium-substituted drugs, such as donafenib, offer notable pharmacokinetic superiorities, including a significantly longer half-life and reduced toxicity compared to conventional chemotherapeutic agents. These characteristics make them promising candidates for cancer chemotherapy. In summary, this review examines the role of deuterium-related molecules in cancer development, detection, and treatment, including DEW, DDW, deuterium-substituted drugs, and deuterium-labeled compounds. Additionally, it highlights the latest advancements in deuterium-labeled compound detection technologies.
Indexed as
Identifiers
40481992What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.