Evidence map›Paper›PMID 40481988›Full record

ArticleJournal of neuro-oncology2025

A prospective study of minimally invasive keyhole craniotomy and stereotactic brachytherapy for new brain oligometastases.

Smruti Mahapatra, Laurel Seltzer, Neydin Osorio, Michelle Miller, Andrew Janssen, Raj Mitra, Joseph Keen, Clayton Smith, Marcus Ware

Erratum issuedAbstract read
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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Smruti MahapatraDepartment of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
Laurel SeltzerDepartment of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
Neydin OsorioDepartment of Neurosurgery, Ochsner Medical Center, 1514 Jefferson Hwy, New Orleans, LA, 70121, USA.
Michelle MillerDepartment of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
Andrew JanssenDepartment of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
Raj MitraDepartment of Radiation Oncology, Ochsner Medical Center, New Orleans, LA, USA.
Joseph KeenDepartment of Neurosurgery, Ochsner Medical Center, 1514 Jefferson Hwy, New Orleans, LA, 70121, USA.
Clayton SmithDepartment of Radiation Oncology, Ochsner Medical Center, New Orleans, LA, USA.
Marcus WareDepartment of Neurosurgery, Ochsner Medical Center, 1514 Jefferson Hwy, New Orleans, LA, 70121, USA. mware@ochsner.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMetastatic brain tumors (MBTs) are the most common intracranial tumors, affecting up to 40% of cancer patients. Traditional treatments such as Whole Brain Radiotherapy (WBRT) and Stereotactic Radiosurgery (SRS) have limitations, including neurocognitive decline and potential tumor regrowth. Minimally invasive keyhole craniotomy (MIKC) and Cesium-131 (Cs-131) brachytherapy offer promising alternatives due to their precision and reduced side effects. This prospective study aims to evaluate the safety and efficacy of combining MIKC with Cs-131 brachytherapy in treating newly diagnosed brain oligometastases.

methodsTwenty-one adults with newly diagnosed brain metastases were enrolled from 2019 to 2021. Preoperative T1 MRI with gadolinium was used to calculate the gross tumor volume (GTV). Minimally invasive craniotomies were performed with resection of these tumors, followed by the implantation of Cs-131 seeds. Postoperative imaging was conducted to verify seed placement and resection. Dosimetric values (V100, V200, D90) were calculated. Patients were followed every two months for two years to monitor local progression, functional outcomes, and quality of life. The primary endpoint was freedom from local progression, with secondary endpoints including overall survival, functional outcomes, quality of life, and treatment-related complications.

resultsThe median preoperative tumor volume was 10.65 cm

conclusionCombining MIKC with Cs-131 brachytherapy is effective for local tumor control and improving functional outcomes in patients with brain oligometastases. Further studies with larger cohorts are needed to validate these findings and refine treatment protocols.

Indexed as

BrachytherapyBrain NeoplasmsCraniotomyMinimally Invasive Surgical ProceduresRadiosurgeryAdultAgedCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesQuality of LifeBrachytherapyBrain metastasisCesium-131Keyhole craniotomyMinimally invasivestereotactic radiosurgery

Identifiers

PMID40481988
PMCPMC12511137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.