Evidence map›Paper›PMID 40481940›Full record

ReviewCurrent HIV/AIDS reports2025

HIV and Pregnancy: Navigating Complex Decision Making and Preventing Perinatal Transmission.

William R Short, Elizabeth D Lowenthal, Florence Momplaisir, Kathleen M Powis, Rachel K Scott, Lynn M Yee, Emily S Miller, Lynne M Mofenson

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William R ShortDepartment of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, 3801 Filbert St, Suite 103B, Philadelphia, PA, 19104, USA. William.short@pennmedicine.upenn.edu.
Elizabeth D LowenthalDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Florence MomplaisirDepartment of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, 3801 Filbert St, Suite 103B, Philadelphia, PA, 19104, USA.
Kathleen M PowisDepartment of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Rachel K ScottMedstar Health and Georgetown University School of Medicine, Washington, DC, USA.
Lynn M YeeDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Emily S MillerDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Lynne M MofensonElizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe objective of this review is to examine the intersection of pregnancy and HIV, focusing on birthing person and fetal health outcomes, prevention of perinatal HIV transmission, and the latest advancements in treatment and care in the United States. It highlights current guidelines, challenges in management, and future directions for improving outcomes. RECENT

findingsHIV treatment guidelines continue to highlight key principles for the choice of antiretroviral therapy in pregnancy, challenges, and strategies for adherence support. Guidelines have been updated to reflect patient-centered counseling to support shared decision making about infant feeding. Counseling should begin prior to pregnancy, and be reviewed throughout pregnancy, again at delivery, and throughout the periods when breast/chestfeeding occurs. ART use during pregnancy has significantly reduced perinatal HIV transmission. Ongoing research and collaboration are vital to addressing remaining challenges. Prioritizing maternal and infant health ensures that ART not only prevents transmission but also improves future health for families affected by HIV.

Indexed as

Decision MakingHIV InfectionsInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousAnti-HIV AgentsCounselingFemaleHumansInfant, NewbornPregnancyUnited StatesAnti-HIV AgentsAntiretroviral therapyHIVPregnancyTeratogenicity

Identifiers

PMID40481940
PMCPMC12145298

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.