ArticleDiscover oncology2025
Mechanisms of Jisheng-Wumei tablet in laryngeal cancer treatment: a network pharmacology analysis of baicalein's targeting of cytochrome C for laryngeal cancer inhibition.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesJisheng-Wumei Tablet (JSWMT) is traditionally used in Chinese medicine for cancer therapy and shows potential efficacy against laryngeal cancer. This study aimed to elucidate the active components of JSWMT, with a specific focus on the role of baicalein in targeting cytochrome C (CYCS) to inhibit laryngeal cancer.
methodsUtilizing network pharmacology, we identified the active ingredients of JSWMT and their corresponding drug targets by leveraging data from the TCMSP and GeneCards databases to pinpoint laryngeal cancer-related targets. Key targets were identified through survival analysis of TCGA expression data, and molecular docking was employed to evaluate the binding affinity between JSWMT compounds and these targets.
resultsOur research identified 35 effective JSWMT ingredients that interact with 132 drug targets, which intersect with 421 targets related to laryngeal cancer. Survival analysis highlighted IL2, CYCS, and CTNNB1 as critical targets significantly correlated with patient survival. Molecular docking demonstrated a strong affinity between CYCS and baicalein, indicating that baicalein is JSWMT's principal active component against laryngeal cancer.
conclusionBaicalein is identified as the key active ingredient in JSWMT, targeting CYCS to inhibit the growth of laryngeal cancer cells. This investigation highlights baicalein's potential mechanism of action and underscores the importance of integrating traditional Chinese medicine with contemporary cancer treatment strategies, offering a novel approach to laryngeal cancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.