Evidence map›Paper›PMID 40481934›Full record

ArticleBiochemical genetics2026

LDHA-Mediated H3K18 Lactylation Promotes the Glycolysis in Non-Small Cell Lung Cancer Through Targeting PTEN.

Yufeng Shao, Xiaomin Duan, Guojian Gu, Qingfeng Zhu, Jian Shu, Fan Fei

Abstract read
PubMed Publisher
In one paragraph

Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. [Advances in Lactate Metabolic Reprogramming in Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026
    Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yufeng Shao *Department of Thoracic Surgery, The First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou, China.
Xiaomin Duan *Department of Nuclear Medicine Department, The First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou, China.
Guojian GuDepartment of Pathology, The First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou, China.
Qingfeng ZhuDepartment of Thoracic Surgery, The First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou, China.
Jian ShuDepartment of Thoracic Surgery, The First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou, China. yuren123456789@163.com.
Fan FeiDepartment of Anesthesiology, The First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou, China. feifan3341@126.com.

Funding

Mandatory Project for Medical and Health Application Basic Research of Taicang Science and Technology Bureau TC2023JCYL04Suzhou Science and Technology Bureau Basic Research Program Guidance Project SKYD2023066Suzhou Science and Technology Development Plan (Basic Research Medical Application Basic Research) SKY2023031Taicang Science and Technology Bureau Medical and Health Application Basic Research Directive Project TC2023JCYL19
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases. Lactylation, a lactate-driven post-translational modification, has been implicated in various tumor pathologies. This study aimed to investigate the role of histone H3 lysine 18 lactylation (H3K18la) in NSCLC progression. Western blot was performed to detect the protein levels of lactylation and H3K18la. Cell counting kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), and Transwell migration assays were performed to detect the cell viability, proliferation, and migration. The 2-deoxy-2-[fluorine-18]fluoro-D-glucose (

Indexed as

Carcinoma, Non-Small-Cell LungGlycolysisHistonesLactate Dehydrogenase 5Lung NeoplasmsPTEN PhosphohydrolaseA549 CellsAnimalsCell Line, TumorCell MovementCell ProliferationHumansL-Lactate DehydrogenaseMiceMice, NudeProtein Processing, Post-TranslationalHistonesLactate Dehydrogenase 5LDHA protein, humanL-Lactate DehydrogenasePTEN PhosphohydrolasePTEN protein, humanGlycolysisH3K18laHistone lactylationMigrationNon-small cell lung cancerProliferation

Identifiers

PMID40481934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.