Evidence map›Paper›PMID 40481884›Full record

ReviewJournal of molecular medicine (Berlin, Germany)2025

PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential.

Chenyang Wang, Xi Chen, Lili Duan, Junfeng Chen, Liaoran Niu, Siyu Wei, Han Bai, Yujie Zhang, Wei Zhou, Jinqiang Liu and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular medicine (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chenyang Wang *Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Xi Chen *Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Lili Duan *Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Junfeng Chen *Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Liaoran NiuDepartment of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Siyu WeiDepartment of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Han BaiDepartment of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Yujie ZhangDepartment of Histology and Embryology, School of Basic Medicine, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Wei ZhouDepartment of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Jinqiang LiuDepartment of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Wanli YangDepartment of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China. 1104387844@qq.com.
Yu HanDepartment of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China. hanyufmmu@126.com.
Liu HongDepartment of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China. hongliufmmu@163.com.ORCID http://orcid.org/0000-0002-8276-2345
Daiming FanState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Funding

National Clinical Research Center for Digestive Diseases 2015BAI13B07National Natural Science Foundation of China 82073210National Natural Science Foundation of China 82303427National Natural Science Foundation of China 82372693
6 · The paper itself

Abstract

Poly(rC)-Binding Protein 2 (PCBP2) stands as a pivotal component within the PCBP family, renowned for its multifaceted roles in both intracellular transcriptional and post-transcriptional regulation processes. The burgeoning body of research illuminates the critical role of PCBP2 expression across a spectrum of solid malignancies. Delving into the intricacies of PCBP2's involvement in cancer genesis opens promising avenues for pioneering diagnostic techniques, therapeutic interventions, and prognostic assessments specifically tailored to gastrointestinal cancers. This review meticulously collates and examines the extant literature on PCBP2's expression dynamics and functional attributes in the oncological context, with a particular focus on gastrointestinal malignancies. Furthermore, it explores the intricate molecular pathways implicated in cancer progression where PCBP2 plays a significant role. Additionally, this discourse encapsulates the prospective clinical utilities of PCBP2, spanning diagnosis, therapeutic modalities, and prognostication in the realm of gastrointestinal cancers.

Indexed as

Gastrointestinal NeoplasmsRNA-Binding ProteinsAnimalsBiomarkers, TumorGene Expression Regulation, NeoplasticHumansPrognosisBiomarkers, TumorPCBP2 protein, humanRNA-Binding ProteinsDiagnosticsGastrointestinal cancerPCBP2PrognosisTherapeutic targets

Identifiers

PMID40481884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.