Trial reportLasers in medical science2025
Additional effect of high-intensity laser therapy with conventional physiotherapy related to pain and function in patients with knee osteoarthritis: a randomized, double-blind, placebo-controlled, 12-week follow-up study.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The importance of power in photobiomodulation: a systematic review and meta-analysis of high-intensity laser therapy.Frontiers in integrative neuroscience · 2026Pooled it
- A narrative review of clinical research on knee osteoarthritis in 2025.Annals of joint · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh-intensity laser therapy (HILT) is a relatively new form of Nd: YAG laser. The aim of the study is to investigate the additional benefits of HILT with conventional physiotherapy, related to pain and function, in patients with knee osteoarthritis (KOA).
methodThe study comprised 43 knees from 31 patients of both genders with mean age 54.6 ± 6.22 (41-64) years. 53.49% of the knees were Kellgren Lawrence (KL) grade 2, and rest were KL grade 3 KOA. Group 1 (n = 21) received transcutaneous electrical nerve stimulation (TENS), hot packs (HP), exercises (EX), and HILT (Nd: yag-laser, 10 W). Group 2 (n = 22), received the same interventions but placebo HILT. All interventions were applied for 10 sessions. The Visual Analog Scale (VAS), Western Ontario & McMaster Universities Osteoarthritis Questionnaire (WOMAC), and Lequesne Algofunctional Index (LAI) were administered before, after, and at 12-week follow-up.
resultsBaseline VAS, WOMAC, and LAI scores of the groups were similar (p > 0.05). After treatment and 12 weeks of follow-up, both groups had significant relief for VAS, WOMAC, LAI pain (respectively, p < 0.001) and function (p < 0.012), except LAI-walking distance (p = 0.415). Post-hoc analyses and mixed-effects models showed no significant differences between groups over time for all variables.
conclusionsHILT did not provide additional short- or mid-term benefits in pain or function when added to a conventional physiotherapy and exercise program in patients with stage 2 or 3 knee osteoarthritis under 65 years of age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.