ArticleArchives of orthopaedic and trauma surgery2025
Personalized bleeding management in total knee arthroplasty using reference change value: comparative analysis of tourniquet versus non-tourniquet techniques.
Article in Archives of orthopaedic and trauma surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTotal knee arthroplasty (TKA) is a commonly performed surgical procedure for the treatment of advanced-stage knee osteoarthritis. This study aims to compare perioperative blood loss between tourniquet-assisted and tourniquet-free TKA using the reference change value (RCV), a personalized analytical tool that accounts for both biological and analytical variability. MATERIALS AND
methodsA retrospective analysis was conducted on 137 patients (tourniquet group (n = 68) and non-tourniquet group (n = 69) who underwent primary TKA. Hematological parameters-including red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT)-were evaluated preoperatively, on the day of surgery, and on postoperative day one. Blood loss was assessed using both conventional statistical methods and RCV-based analysis.
resultsNo statistically significant differences were observed between the two groups in terms of age and gender (p > 0.05). Although preoperative hemoglobin levels were significantly different between groups (p < 0.05), there were no significant intergroup differences in pre- or postoperative RBC and HCT values. Traditional statistical analysis showed no significant difference in blood loss (p > 0.05). However, RCV analysis revealed that while bleeding had stabilized by the first postoperative day in the non-tourniquet group, it remained significantly elevated in the tourniquet group.
conclusionsThe findings suggest that RCV offers a more individualized and sensitive approach to assessing perioperative blood loss in TKA. Although conventional methods did not demonstrate significant differences, RCV analysis indicated a more rapid hemostatic response in the non-tourniquet group. Incorporating RCV into routine clinical practice may enhance patient-specific blood management and support earlier postoperative decision making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.