Evidence map›Paper›PMID 40481843›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025

Bone-enhanced 3D ultrasound: a non-ionizing alternative for pediatric scoliosis assessment.

Tamas Ungi, Catherine O Wu, Sarah J D Dance, Charles Lawall, Charles Nagel, Gregg Khodorov, Robert W Ford, Kevin Cleary, Gabor Fichtinger, Matthew E Oetgen and 1 more

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tamas UngiQueen's University, Kingston, Canada. ungi.tamas@gmail.com.
Catherine O WuQueen's University, Kingston, Canada. catherine.wu@queensu.ca.
Sarah J D DanceChildren's National Hospital, Washington, USA.
Charles LawallThomas Jefferson University, Philadelphia, USA.
Charles NagelThomas Jefferson University, Philadelphia, USA.
Gregg KhodorovThomas Jefferson University, Philadelphia, USA.
Robert W FordThomas Jefferson University, Philadelphia, USA.
Kevin ClearyChildren's National Hospital, Washington, USA.
Gabor FichtingerQueen's University, Kingston, Canada.
Matthew E OetgenChildren's National Hospital, Washington, USA.
Daniel P BorschneckQueen's University, Kingston, Canada.

Funding

NIH HHS 1R01EB021396-01A1
6 · The paper itself

Abstract

purposeScoliosis affects up to 5% of the population, and early detection is crucial to prevent progression and surgical intervention. X-ray imaging remains the standard for scoliosis assessment, but repeated exposure to ionizing radiation increases cancer risks, particularly in pediatric patients. This study evaluates bone-enhanced 3D ultrasound (BEUS) as a non-ionizing alternative for scoliosis measurement.

methodsWe conducted a comparative analysis of X-ray and BEUS measurements in 34 pediatric patients. Each participant underwent same-day spinal imaging with both modalities. Scoliosis angles were measured independently by two observers using anatomical landmarks visible in both imaging modalities. Statistical tests assessed agreement between X-ray and BEUS, inter-observer variability, and potential biases.

resultsMinimal inter-observer variability was found (intraclass correlation coefficient = 0.98). 93% of BEUS measurements fell within a clinically acceptable ± 5° range of X-ray values. Regression analysis identified age and scoliosis severity as significant predictors of measurement differences (p < 0.05). In particular, error increased with scoliosis severity, with curvatures above 40° showing significant deviation.

conclusionBEUS is a promising alternative for scoliosis assessment, demonstrating strong reliability for mild to moderate cases while eliminating radiation exposure. BEUS holds potential for routine scoliosis monitoring, reducing reliance on X-rays and minimizing radiation risk in pediatric patients.

Indexed as

Imaging, Three-DimensionalScoliosisSpineAdolescentChildFemaleHumansMaleRadiographyReproducibility of ResultsUltrasonographyNon-ionizing radiationPediatric spine monitoringScoliosisUltrasound

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.