Trial reportEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Effect of intratympanic corticosteroid on otitis media with effusion: A randomized clinical trial.
Trial report in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the effectiveness of intratympanic corticosteroid (ITS) therapy compared to standard therapy alone in improving hearing and tympanometric outcomes in adults with unilateral and bilateral OME.
methodsA randomized controlled clinical trial was conducted with 56 adult patients at Taleghani Hospital, Tehran. Participants were assigned to either a control group receiving standard therapy (saline irrigation and intranasal corticosteroids) or an experimental group receiving intratympanic corticosteroid injections in addition to standard therapy. Hearing thresholds and tympanometric results were assessed at one-month, two-month, and three-month follow-ups.
resultsAt one month, the ITS group demonstrated greater improvement in hearing than the control group (mean air-bone gap 16.4 dB vs 24.7 dB; p = 0.019). By two months, 43.8% of ITS-treated patients achieved a Type A tympanogram compared to 16.7% of controls (p < 0.001). At three months, 74% versus 66.7% of patients had Type A tympanograms (ITS vs control; p = 0.005), indicating a narrowing difference as the control group improved. No significant adverse effects were observed.
conclusionIntratympanic corticosteroid therapy is an effective treatment for OME in adults, significantly improving hearing and middle ear function compared to standard therapy alone.
Indexed as
Identifiers
40481836What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.