Effect of a standardised Ophytrium-containing shampoo and a leave-on mousse protocol on dogs with irritated and pruritic skin.

objectivesTopical formulations are helpful and versatile management modalities for skin disorders. However, veterinary studies assessing their efficacies are limited. This study evaluated the effects of a protocol comprising the combined application of an Ophytrium-based shampoo and a leave-on mousse (DOUXO MATERIALS AND

methodsA multicentre, open-label, uncontrolled trial  was conducted at 12 veterinary clinics in France, Spain and the United States. Included dogs underwent shampoo application on Day 0 (D0), followed by eight sessions of mousse application at 2- to 3-day intervals. Canine Atopic Dermatitis Extent and Severity Index-4 (CADESI-04) scores assessed by veterinarians and pruritus visual analogue scale (PVAS) scores reported by owners were evaluated weekly.

resultsThirty-four dogs with atopy were included. The mean CADESI-04 score decreased significantly from 24.2 on D0 to 11.9 on Day 21 (D21), with 61.8% of the dogs achieving ≥50 decrease in their CADESI-04 scores by D21. Additionally, the mean PVAS score decreased significantly from 5.3 on D0 to 3.6 on D21, with 44.1% of the dogs exhibiting ≥50% decrease in their PVAS scores by D21. Veterinarians considered the improvements to be satisfactory, good or excellent in 66.7% of cases. Pet owners were satisfied with the performance of the protocol in 72.7% of cases. CLINICAL SIGNIFICANCE: The standardized topical protocol described herein, when used alone or as an adjuvant treatment to systemic therapy, significantly improved both CADESI-04 scores and pruritus in atopic dogs presenting with skin flares and mild-to-moderate intensity skin lesions.