ArticleAngewandte Chemie (International ed. in English)2025
Synthesis of Versatile DNA-Conjugated Aldehydes by Controlled Oxidation of Amines.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Unleashing the power of DNA-encoded libraries for challenging targets in drug discovery.Pharmaceutical science advances · 2026Review
- Highly selective and AI-predictable Se-N exchange chemistry between benzoselenazolones and boronic acids for programmable, parallel, and DNA-encoded library synthesis.Chemical science · 2026Article
- Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform.Journal of the American Chemical Society · 2025Article
- Synthesis of Versatile DNA-Conjugated Aldehydes by Controlled Oxidation of Amines.Angewandte Chemie (International ed. in English) · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Aldehyde-functionalized oligonucleotides have found diverse applications in chemical biology and material science. However, due to the electrophilic nature of aldehydes, incorporating aldehyde functionalities directly into DNA is challenging, particularly for highly reactive alkyl aldehydes. Inspired by natural oxidases, we herein developed a controlled oxidation strategy to generate aldehyde-functionalized DNAs from synthetically accessible DNA-conjugated amines in situ. A broad range of DNA-conjugated alkyl and aryl aldehydes were efficiently produced from the corresponding amines using O
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