Evidence map›Paper›PMID 40481620›Full record

ReviewJournal of the International Society of Sports Nutrition2025

Creatine and post-viral fatigue syndrome: an update.

Sergej M Ostojic, Daren G Candow, Mark A Tarnopolsky

Abstract readReview
In one paragraph

Review in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sergej M OstojicUniversity of Agder, Department of Nutrition and Public Health, Kristiansand, Norway.ORCID 0000-0002-7270-2541
Daren G CandowUniversity of Regina, Faculty of Kinesiology and Health Studies, Regina, SK, Canada.ORCID 0000-0002-6655-4482
Mark A TarnopolskyDepartment of Pediatrics, McMasterChildren's Hospital, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-viral fatigue syndrome, classified as a neurological condition by the WHO (ICD-11 code: 8E49), manifests as persistent fatigue, cognitive difficulties, and post-exertional malaise following viral infections. It shares commonalities with chronic fatigue syndrome and myalgic encephalomyelitis but is distinct due to its association with preceding viral events. Emerging research identifies bioenergetic disruptions, particularly mitochondrial dysfunction and impaired creatine metabolism, as key contributors. Recent studies suggest creatine supplementation may alleviate symptoms and improve energy metabolism. This narrative review summarizes recent advancements in utilizing creatine as a diagnostic and therapeutic target for post-viral fatigue syndrome and explores future directions for its application in managing this perplexing condition.

Indexed as

CreatineFatigue Syndrome, ChronicVirus DiseasesDietary SupplementsEnergy MetabolismHumansCreatinebioenergeticsbrain metabolismclinical symptomsCreatine monohydratefatigue

Identifiers

PMID40481620
PMCPMC12147496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.