SynthesisClinical epigenetics2025
DNA methylation in monozygotic twins discordant for acute lymphoblastic leukemia: a case report and systematic review.
Synthesis in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Preliminary Analysis of CpG, CHG and CHH Methylation in the Mitochondrial Control Region of Dogs With Malignant Mammary Gland Tumours.Animal genetics · 2026Article
- Evolutionary Restructuring and Systematic Review of theJournal of developmental biology · 2026Review
- Concurrent MLL-AF4Frontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute lymphoblastic leukemia (ALL) is a prevalent malignant hematologic disease characterized by the abnormal proliferation and accumulation of immature lymphocytes in bone marrow and lymphoid tissues. In our study, Oxford Nanopore Technologies (ONT) sequencing was performed to investigate four types of methylation modifications-6 mA, CHG, CHH, and CpG-in a pair of monozygotic twins, where one twin has ALL and the other is healthy. The results showed the significant global hypomethylation of CpG sites and an increase in 6 mA, CHG, and CHH methylation in the twin diagnosed with ALL. Notably, the hypomethylation of CpG was particularly increased in the open sea, gene body, and 3'UTR regions, while 6 mA and CHG modifications exhibited high methylation levels in the gene body, TSS1500, TSS200, and 3'UTR regions. Additionally, CHH modifications showed high methylation across all genomic regions. Within the differential methylation loci (DML), we identified several genes related to tumorigenesis and progression (such as ZDHHC11, NBPF1, and TPTE). Furthermore, we systemically reviewed the literatures on leukemia and DNA methylation modifications, providing a comprehensive description of their correlation. In summary, these findings indicate that DNA methylation plays a crucial role in the onset and progression of ALL, offering valuable insights for future research into its impact on leukemia development.
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Registered trials
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