Evidence map›Paper›PMID 40481562›Full record

ReviewEuropean journal of medical research2025

Biological interpretation of DNA/RNA modification by ALKBH proteins and their role in human cancer.

Siqi Yang, Jixiang Xing, Yancheng Song, Jiafu Cui, Lingling Bao, Qilemuge Xi, Yongchun Zuo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siqi YangState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Jixiang XingState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Yancheng SongState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Jiafu CuiState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Lingling BaoState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China.
Qilemuge XiState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China. qlmgxi@imu.edu.cn.
Yongchun ZuoState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China. yczuo@imu.edu.cn.

Funding

China Postdoctoral Science Foundation under Grant Number 2024MD763987Group Project of Developing Inner Mongolia through Talents 2025TEL25National Natural Scientific Foundation of China 62171241National Natural Scientific Foundation of China 62461046
6 · The paper itself

Abstract

AlkB homolog (ALKBH) belongs to 2-oxoglutarate (2OG) and ferrous iron-dependent oxygenases, which can catalyze the demethylation of DNA/RNA and play an important role in human diseases represented by cancer. Although ALKBH has been extensively studied, the biological explanation for its specific recognition of DNA/RNA and its mechanism of action in cancer remains unclear. This review explores the molecular mechanism of ALKBH protein binding to DNA/RNA through structural fitting and ChIP-Seq analysis and summarizes the structural biology factors that lead to its specific substrate recognition. Furthermore, the expression of ALKBH protein across different tissues is systematically compiled, with a tissue-specific expression map generated for 15 organs and 50 tissues. These maps provide valuable insights into the protein's function in various physiological contexts. Additionally, this review systematically summarizes the regulatory role of the ALKBH protein in the occurrence and development of cancer. It highlights the protein's involvement in key signaling pathways, including Wnt, AKT, AMPK, NF-κB, Hippo, and Notch, revealing its potential for application in early diagnosis and targeted cancer therapy. Overall, this review comprehensively expounds the biological functions of the ALKBH protein and its important role in cancer, which has important theoretical value and application prospects.

Indexed as

AlkB EnzymesDNANeoplasmsRNAHumansAlkB EnzymesDNARNADNA/RNA recognitionOmics analysisSignaling pathwaysStructural topologyTissue-specific expression

Identifiers

PMID40481562
PMCPMC12142999

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.