Evidence map›Paper›PMID 40481495›Full record

ArticleBMC veterinary research2025

Anthelmintic activity of winter savory (Satureja montana L.) essential oil against gastrointestinal nematodes of sheep.

Filip Štrbac, Slobodan Krnjajić, Radomir Ratajac, Laura Rinaldi, Vincenzo Musella, Fabio Castagna, Dragica Stojanović, Nataša Simin, Dejan Orčić, Antonio Bosco

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Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Current Knowledge of the GenusPharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Filip ŠtrbacInstitute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia. filip.strbac@imsi.bg.ac.rs.
Slobodan KrnjajićInstitute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia.
Radomir RatajacScientific Veterinary Institute Novi Sad, Novi Sad, Serbia.
Laura RinaldiDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, CREMOPAR, Naples, Italy.
Vincenzo MusellaDepartment of Health Sciences, University of Catanzaro Magna Græcia, Catanzaro, Italy.
Fabio CastagnaDepartment of Health Sciences, University of Catanzaro Magna Græcia, Catanzaro, Italy.
Dragica StojanovićDepartment of Veterinary Medicine, Faculty of Agriculture, University of Novi Sad, Novi Sad, Serbia.
Nataša SiminDepartment of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Dejan OrčićDepartment of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Antonio BoscoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, CREMOPAR, Naples, Italy. antonio.bosco@unina.it.

Funding

Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Italy Project "CREMOPAR"Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja rescript no. 451-03-1183/2021-14
6 · The paper itself

Abstract

backgroundThe increasing difficulties in combating anthelmintic resistance in gastrointestinal nematodes (GINs) of sheep worldwide, and the residues of chemical drugs in animal products and the environment, necessitate the search for alternatives. Previous studies have shown that plant essential oils (EOs) could be valuable anthelmintic agents, due to their numerous advantages. The present study aimed to evaluate the possibility of using winter savory (Satureja montana L.) EO against sheep GINs. The chemical composition of the tested oil was determined by gas chromatography-mass spectrometry (GC-MS). The efficacy of the tested oil was determined in vitro using the egg hatch test (EHT), and in vivo using the faecal egg count reduction test (FECRT) performed in two farms. Preliminary toxicity studies including clinical observation, haematological and biochemical blood analysis were also performed to evaluate the safety of the tested oil to the hosts. In addition, a coproculture study was carried out in the tested farms using the appropriate morphological keys.

resultsMain compounds of the S. montana oil identified by GC-MS analysis were p-cymene (42.8%), carvacrol (28.1%) and y-terpinene (14.6%). The in vitro EHT showed a dose-dependent (R

conclusionThe anthelmintic potential showed on EHT and FECRT, without adverse effects on the sheep, suggests that S. montana EO is suitable for the control of sheep GINs as part of an integrated parasite management. However, further studies should be conducted to increase efficacy in field conditions.

Indexed as

AnthelminticsGastrointestinal DiseasesNematodaNematode InfectionsOils, VolatilePlant OilsSaturejaSheep DiseasesAnimalsCymenesFecesFemaleGas Chromatography-Mass SpectrometryMaleParasite Egg CountSheepAnthelminticsCymenesOils, VolatilePlant OilsAnthelmintic drug residuesAnthelmintic resistanceBotanical anthelminticsChemical analysesCoprocultureIntegrated parasite controlIn vitro testIn vivo testToxicity study

Identifiers

PMID40481495
PMCPMC12144719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.