ArticleBMC geriatrics2025
Systemic immune-inflammatory index mediates the association between regular walking and depression in the elderly with coronary heart disease.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundDepressive disorders and coronary heart disease (CHD) are significant and pervasive global public health challenges, influenced by various factors such as diet, physical activity, social circumstances, and lifestyle habits. This study aim to investigate the relationship among regular walking, the systemic immune-inflammation index (SII), and depression in CHD patients. Additionally, it seeks to explore the mediating role of SII in the effect of regular walking on depression among these patients.
methodsThis cross-sectional study involved 464 patients aged ≥ 65 years with CHD, admitted to the cadre ward of the First Hospital of Jilin University from September 2021 to December 2022. A comprehensive geriatric assessment (CGA) inventory was prepared by compiling and screening regular walking, calculated SII, and the Geriatric Depression Scale (GDS). Binary logistic regression was employed to examine the relationship among walking, ln(SII) and depression. After adjusting for confounding factors, linear regression analysis was used to assess the correlation among exercise-related factors, ln(SII) and depression. Sensitivity analyses were performed through stratified analysis, investigating the relationship between walking and depression within the strata of each variable, as well as the P-interaction among stratified variables. Additionally, the Process package in SPSS was used to explore the mediating role of ln(SII) in the association between regular walking and depression.
resultsModel 2: Elderly individuals who walk regularly are 72.2% less likely to experience depression compared to those who do not engage in regular walking (odds ratio (OR) = 0.278, 95% CI = 0.178-0.433, P < 0.001). However, one-unit increases in ln(SII) corresponds to an approximately sixfold in the likelihood of depression among elderly individuals (OR = 5.899, 95% CI = 4.183-8.318, P < 0.001). Model 3: Participants who walk regularly are 69.4% less likely to suffer from depression compared to those who do not walk regularly (OR = 0.306, 95% CI = 0.190-0.491, P < 0.001). Similarly, a one-unit increase in ln(SII) is associated with an approximately sixfold increase in the probability of depression elderly individuals (OR = 5.976, 95% CI = 4.126-8.656, P < 0.001). The stratified analysis examining the effect of regular walking on depression in patients with CHD confirms the robustness of these associations. Additionally, SII was found to mediate the relationship between regular walking and depression in CHD patients, accounting for 43.19% of the total effect.
conclusionsAn interaction exists among SII, regular walking and depression in elderly patients with coronary heart disease. Furthermore, SII partially mediates the relationship between regular walking and depression. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.