ArticleNature methods2025
Benchmarking methods for mapping functional connectivity in the brain.
Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- netneurotools: a trainee-oriented approach to network neuroscience.Nature protocols · 2026Review
- State-dependent signal flow hierarchy in the human cerebral cortex.Nature neuroscience · 2026Article
- Convergence of TMS Sites and Lesion Locations Associated With Nicotine Addiction Improvement on a Common Brain Circuit.The American journal of psychiatry · 2026Article
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- Neurobiological and behavioral relevance of intrinsic functional connectome constraints on task-evoked neural activation.iScience · 2026Article
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Combining phase analysis and causal stimulation enables longitudinal mesoscale connectivity mapping.bioRxiv : the preprint server for biology · 2026Article
- HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.bioRxiv : the preprint server for biology · 2026Article
- Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting.Nature communications · 2026Article
- Synergistic and redundant information dynamics exhibit dissociable alterations across schizophrenia and neurodevelopmental conditions.Brain informatics · 2026Article
- Benchmarking resting state fMRI connectivity pipelines for classification: robust accuracy despite processing variability in cross-site eye state prediction.Brain informatics · 2026Article
- Mapping Functional Brain Organization Using Artificial Intelligence.Chemical & biomedical imaging · 2026Review
- Resting-state fMRI foundation models enable robust and generalizable latent neural target discovery in cognitive aging interventions.bioRxiv : the preprint server for biology · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Normative Modeling of Static and Dynamic Functional Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Towards an informational account of interpersonal coordination.Nature reviews. Neuroscience · 2026Review
- The motion sensitivity and predictive utility of different estimates of interregional functional coupling in resting-state functional MRI.Network neuroscience (Cambridge, Mass.) · 2026Article
- Year in review 2025.Nature methods · 2026Article
- Feature similarity, a sensitive method to capture the functional interaction of brain regions and networks to support flexible behavior.Communications biology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The networked architecture of the brain promotes synchrony among neuronal populations. These communication patterns can be mapped using functional imaging, yielding functional connectivity (FC) networks. While most studies use Pearson's correlations by default, numerous pairwise interaction statistics exist in the scientific literature. How does the organization of the FC matrix vary with the choice of pairwise statistic? Here we use a library of 239 pairwise statistics to benchmark canonical features of FC networks, including hub mapping, weight-distance trade-offs, structure-function coupling, correspondence with other neurophysiological networks, individual fingerprinting and brain-behavior prediction. We find substantial quantitative and qualitative variation across FC methods. Measures such as covariance, precision and distance display multiple desirable properties, including correspondence with structural connectivity and the capacity to differentiate individuals and predict individual differences in behavior. Our report highlights how FC mapping can be optimized by tailoring pairwise statistics to specific neurophysiological mechanisms and research questions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.