ReviewReproductive sciences (Thousand Oaks, Calif.)2025
Macrophage Plasticity and Extracellular Vesicles in Endometriosis: Immunopathology and Therapeutic Perspectives.
Review in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Role of Macrophages in Endometrial Cyclical Changes and Female Reproductive System Diseases: A Review.Current issues in molecular biology · 2026Review
- Associations between aggregate index of systemic inflammation and endometriosis risk utilizing logistic regression analysis.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis, as a chronic gynecological condition, includes irregular endometrial cell growth beyond the uterus, which creates pelvic pain and infertility, together with inflammatory disease throughout the body. Currently, about 10% of all women worldwide experience this disease, but scientists have not determined its natural causes. Importantly, the development of endometriosis depends significantly on the dysfunction of the immune system, which results in impaired macrophage activity. Specifically, endometriotic lesions contain M2-like macrophages, supporting tissue reconstruction along new blood vessel formation and evading immune responses. Moreover, the survival of lesions and the processes of neurogenesis and inflammation depend on the actions of macrophage-derived extracellular vesicles (EVs) as well as cytokines and growth factors. In this context, this review investigates the process of macrophage polarization and details the cellular interactions found in endometriotic tissue environments and their therapeutic capacity. Ultimately, understanding the underlying mechanisms of disease will facilitate the development of immunomodulatory therapies aimed at reducing symptoms and improving clinical outcomes.
Indexed as
Identifiers
40481352What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.