ArticleDiscover oncology2025
The expression and prognosis for Aurora kinases in human non-small cell lung cancer.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase.Scientific reports · 2026Article
- Mitotic Machinery Dysregulation in Lung Cancer: Biological Roles, Therapeutic Targeting, and Combination Strategies.Pharmaceutics · 2026Review
- Atypical R-loops in cancer: decoding molecular chaos for therapeutic gain.Journal of translational medicine · 2025Review
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Authors and funding
4 authors.
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Abstract
backgroundAurora kinases (AURKs), members of the serine/threonine kinases gene family, have been implicated in various human cancers, including lung cancer. However, the expression and clinical significance of AURKA, AURKB, and AURKC in non-small cell lung cancer (NSCLC) remain unclear.
methodsComprehensive bioinformatics analyses were conducted using databases such as The Cancer Genome Atlas (TCGA), Gene Expression Profiling Interactive Analysis (GEPIA), and Kaplan-Meier Plotter. Immunohistochemistry (IHC) was performed on tissue microarrays (TMAs) from 29 lung adenocarcinoma (LUAD) patients. AURKA/B knockdown and overexpression cell models were successfully established in LUAD cells. The proliferative capacity of the stable cells was assessed using colony formation assays and CCK-8 assays.
resultsAURKA and AURKB were upregulated in lung cancer tissues compared to normal, while AURKC was downregulated. High expression of AURKA and AURKB was associated with advanced tumor stage and poor survival outcomes in LUAD patients. AURKA and AURKB expression levels correlated with immune cell infiltration and immune checkpoint genes, suggesting potential roles in immunotherapy. In vitro experiments have demonstrated that AURKA and AURKB played crucial roles in promoting proliferation of LUAD cells.
conclusionThis study highlights the prognostic value of AURKA and AURKB in NSCLC, particularly LUAD, and identifies them as potential therapeutic targets or prognostic biomarkers.
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