Evidence map›Paper›PMID 40481302›Full record

ArticleCommunications medicine2025

Childhood predictors of suffering in adulthood across 22 countries.

Richard G Cowden, Zhuo Job Chen, Renae Wilkinson, Dorota Weziak-Bialowolska, Thomas Breedlove, Craig Gundersen, Koichiro Shiba, R Noah Padgett, Byron R Johnson, Tyler J VanderWeele

Abstract read
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richard G CowdenHuman Flourishing Program, Institute for Quantitative Social Science, Harvard University, Cambridge, MA, USA. rcowden@fas.harvard.edu.ORCID http://orcid.org/0000-0002-9027-4253
Zhuo Job ChenSchool of Nursing, University of North Carolina at Charlotte, Charlotte, NC, USA.
Renae WilkinsonHuman Flourishing Program, Institute for Quantitative Social Science, Harvard University, Cambridge, MA, USA.
Dorota Weziak-BialowolskaHuman Flourishing Program, Institute for Quantitative Social Science, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2711-2283
Thomas BreedloveInstitute for Studies of Religion, Baylor University, Waco, TX, USA.
Craig GundersenDepartment of Economics, Baylor University, Waco, TX, USA.
Koichiro ShibaDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
R Noah PadgettHuman Flourishing Program, Institute for Quantitative Social Science, Harvard University, Cambridge, MA, USA.
Byron R JohnsonHuman Flourishing Program, Institute for Quantitative Social Science, Harvard University, Cambridge, MA, USA.
Tyler J VanderWeeleHuman Flourishing Program, Institute for Quantitative Social Science, Harvard University, Cambridge, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence suggests that suffering may degrade health and well-being. However, further research is needed to identify potential targets for addressing population-level suffering.

methodsThis cross-sectional study used nationally representative data from 22 countries in Wave 1 of the Global Flourishing Study (N = 202,898) to explore associations of 13 individual characteristics and retrospectively recalled childhood factors with suffering in adulthood. We conducted a modified Poisson regression by country in which suffering was regressed on all candidate predictors. Random effects meta-analyses were used to aggregate results for the 11 predictors that were common across all countries.

resultsOur meta-analytic results suggest that a combination of risk and protective factors during childhood may be associated with suffering in adulthood. Individuals whose parents were married (versus divorced) at age 12, had a very good/somewhat good paternal relationship (versus very bad/somewhat bad) when growing up, had excellent health (versus good) when growing up, and who reported their family lived comfortably (versus got by) financially when growing up are less likely to experience suffering in adulthood, whereas those who were abused during childhood (versus not), felt like an outsider in their family when growing up (versus not), attended religious services 1-3 times a month (versus never) around age 12, and are female (versus male) have a higher likelihood of suffering in adulthood. Associations are somewhat heterogeneous across the countries.

conclusionsChildhood experiences, influences, and conditions may impact experiences of suffering in adulthood. Targeted early-life interventions could mitigate the burden of suffering later in life.

Identifiers

PMID40481302
PMCPMC12144105

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.