Evidence map›Paper›PMID 40481262›Full record

ArticleScientific reports2025

Analysis and risk assessment of nitrosamines in sartans using GC-MS and Monte Carlo simulation.

Fatemeh Shomali, Zahra Talebpour, Ghazaleh Abedi, Nilufar Mousavi, Shiva Mokhtarifar, Marjan Kohandani, Vahideh Mahdavi, Noushin Adib

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fatemeh ShomaliDepartment of Analytical Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran, Iran.
Zahra TalebpourDepartment of Analytical Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran, Iran. ztalebpour@alzahra.ac.ir.
Ghazaleh AbediAnalytical and Bioanalytical Research Centre, Alzahra University, Vanak, Tehran, Iran.
Nilufar MousaviAnalytical and Bioanalytical Research Centre, Alzahra University, Vanak, Tehran, Iran.
Shiva MokhtarifarDepartment of Analytical Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran, Iran.
Marjan KohandaniDepartment of Analytical Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran, Iran.
Vahideh MahdaviIranian Research Institute of Plant Protection (IRIPP), Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran.
Noushin AdibFood and Drug Laboratory Research Center, Food and Drug Administration, Ministry of Health, Tehran, Iran. n.adib@fda.gov.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise detection of nitrosamines at very low levels in various substances is crucial because of their known toxicity and potential to cause genetic mutations. As a result, regulations have been established to evaluate the risk of nitrosamines and manage their presence in pharmaceuticals. In this study, we developed an analytical method involving solvent extraction and gas chromatography-mass spectrometry for the determination of N-nitrosodimethylamine and N-nitrosodiethylamine based on the internal standard method. According to validated results based on ICH guidelines, calibration curves spanned from 2.5 to 40 ng mL

Indexed as

Gas Chromatography-Mass SpectrometryNitrosaminesDimethylnitrosamineHumansMonte Carlo MethodRisk AssessmentDimethylnitrosamineNitrosaminesGC-MSNitrosaminesPharmaceuticalQuality controlRisk assessment

Identifiers

PMID40481262
PMCPMC12144120

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.