Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Zicong Huang *Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.
Runduan Yi *Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.ORCID http://orcid.org/0009-0000-1152-553X
Xixian Cen *Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.ORCID http://orcid.org/0009-0002-2650-2781
Hanbin ZhangDepartment of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Minyu XieDepartment of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Ke MaGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.
Shipeng RuanGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.ORCID http://orcid.org/0009-0002-2337-9407
Yuge ZhuangGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.ORCID http://orcid.org/0000-0002-6564-8989
Xiaoyuan ZhangGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.ORCID http://orcid.org/0000-0002-2462-3953
Wenyuan LiuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.ORCID http://orcid.org/0009-0006-5539-1223
Hongrui FengGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.ORCID http://orcid.org/0009-0008-2069-0789
Deyu ChenMedical School, Fuyang Normal University, Fuyang, Anhui, China.
Mohamed Morsi M AhmedDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Hong LiuReproductive Center, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University (Shenzhen Maternity & Child Healthcare Hospital), Shenzhen, Guangdong, PR China. zlhhong@126.com.ORCID http://orcid.org/0000-0002-0498-2203
Chuyu HuangCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China. 649876032@qq.com.ORCID http://orcid.org/0000-0002-1633-8570
Xiangjin KangDepartment of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China. xiangjinkang@gzhmu.edu.cn.ORCID http://orcid.org/0000-0001-7377-7169
Zhenguo ChenGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China. czg1984@smu.edu.cn.ORCID http://orcid.org/0000-0003-3280-5201
Funding
National Natural Science Foundation of China (National Science Foundation of China) 32171113, 31972910, 32200931
6 · The paper itself
Abstract
Centriolar satellites facilitate the delivery of proteins required for centrosome assembly and function, and rely on the nucleation of the scaffold protein pericentriolar material 1 (PCM1). During sperm maturation, centrosomes undergo remodeling to facilitate neckpiece formation and flagellogenesis. However, the role and mechanism of PCM1 in centrosome remodeling and sperm maturation remain to be elucidated. Herein we show that PCM1 is downregulated in patients with non-obstructive azoospermia. Pcm1 knockout mice exhibit disrupted spermiogenesis, characterized by a disorganized manchette and head-tail coupling apparatus, defective flagellogenesis, and male infertility. Mechanistically, PCM1 binds centrosomal proteins and governs their precise translocation via intra-manchette transport, ensuring proper centrosome remodeling and axoneme biogenesis. Inactivation of PCM1 in sperm leads to severe retardation of embryo development, which cannot be overcome by intra-cytoplasmic sperm injection. Collectively, these findings establish PCM1 as a key regulator of spermatogenesis and spermiogenesis, highlighting the contribution of sperm centrosome-related proteins to embryo development and fertility.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation. · full record | OpenQuestion