ArticleNature neuroscience2025
Noninvasive reduction of neural rigidity alters autistic behaviors in humans.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Longitudinal brain dynamics and prediction of craving changes in individuals with methamphetamine use disorder.Translational psychiatry · 2026Article
- Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.Biological psychiatry global open science · 2026Article
- A key gene modulating oxytocin efficacy in autism: genome-wide discovery and verification in randomized controlled trials datasets.Molecular psychiatry · 2026Article
- State-Dependent Modulation of a Theta-Responsive Subnetwork by High-Frequency Stimulation of the Ventral Striatum.Neuroscience bulletin · 2026Article
- Characteristic spatiotemporal features of large-scale functional network architecture in posttraumatic stress disorder.Translational psychiatry · 2026Article
- Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity.Nature communications · 2026Article
- Identification of Children With Autism Spectrum Disorder Based on Multidimensional EEG Feature Fusion Across Temporal-Spectral-Spatial Domains.Alpha psychiatry · 2026Article
- The spectrum of neurodevelopmental disorders: comorbidities as clues to pathogenesis.Current opinion in psychiatry · 2026Review
- State-space kinetic Ising model reveals task-dependent entropy flow in sparsely active nonequilibrium neuronal dynamics.Nature communications · 2025Article
- Autism Spectrum Disorder: Nature vs. Nurture.Missouri medicineArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Autistic behaviors correlate with reductions in specific brain-state transitions in global neural dynamics, implying that the mitigation of such rigid brain dynamics may alter autistic traits. To examine this possibility, we investigated longitudinal behavioral effects of state-dependent transcranial magnetic stimulation (TMS) in autistic adults. We found that excitatory TMS over the right parietal lobule decreased neural rigidity, which commensurately reduced social and nonsocial autistic behaviors. Specifically, TMS-induced neural flexibility immediately decreased cognitive inflexibility and slowly reduced overstable perception and atypical nonverbal communication. In particular, perceptual overstability was reduced after TMS-induced neural flexibility strengthened the coupling between the frontoparietal and visual networks, whereas atypical nonverbal communication became less explicit when the neural flexibility enhanced the coupling between the frontoparietal, default mode and salience networks. These results indicate that alteration of neural rigidity could change multiple autistic traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.