Evidence map›Paper›PMID 40481144›Full record

ArticleCommunications biology2025

Unraveling the SOX11-IGF2 signaling axis in early lung development: implications for lung disease.

Jing Zhang, Xiaoyue Sun, Jingyi Lai, Liyan Wang, Feifei Li, Chunwei Cao

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing ZhangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Xiaoyue SunGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Jingyi LaiDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, China.
Liyan WangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Feifei LiDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, China.ORCID http://orcid.org/0000-0003-3831-5166
Chunwei CaoGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. caochw5@mail.sysu.edu.cn.ORCID http://orcid.org/0009-0008-0924-3582

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32170612Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2024A1515012871
6 · The paper itself

Abstract

The essential function of SOX11 in directing mammalian organogenesis is well-established. Nevertheless, the intricate signaling network it orchestrates, especially during early lung development, remains poorly understood. This study delves into the role of SOX11 in early lung development using a Sox11 knockout mouse model. Developmental analyses reveal that pulmonary malformations emerge during branching morphogenesis, characterized by defective epithelial-mesenchymal condensation and reduced intercellular spacing. By E18.5, Sox11

Indexed as

Insulin-Like Growth Factor IILungLung DiseasesSignal TransductionSOXC Transcription FactorsA549 CellsAnimalsGene Expression Regulation, DevelopmentalHumansMiceMice, KnockoutOrganogenesisIGF2 protein, mouseInsulin-Like Growth Factor IISox11 protein, mouseSOXC Transcription Factors

Identifiers

PMID40481144
PMCPMC12144134

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.