Evidence map›Paper›PMID 40481024›Full record

ArticleScientific reports2025

405 nm light microbicidal efficacy on Treponema pallidum spiked in ex vivo human platelets.

Oksana Yakovleva, Teresa Pilant, Pravin Kaldhone, Joseph Jackson, David Rotstein, Caitlin Stewart, John Anderson, Scott MacGregor, Michelle Maclean, Luisa Gregori and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Oksana YakovlevaDivision of Emerging Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
Teresa PilantDivision of Emerging Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
Pravin KaldhoneDivision of Blood Components and Devices, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, 20993, USA.
Joseph JacksonDivision of Blood Components and Devices, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, 20993, USA.
David RotsteinDivision of Food Compliance, Office of Surveillance and Compliance, Center for Veterinary Medicine, FDA, Rockville, MD, 20855, USA.
Caitlin StewartThe Robertson Trust Laboratory for Electronic Sterilization Technologies, Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK.
John AndersonThe Robertson Trust Laboratory for Electronic Sterilization Technologies, Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK.
Scott MacGregorThe Robertson Trust Laboratory for Electronic Sterilization Technologies, Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK.
Michelle MacleanThe Robertson Trust Laboratory for Electronic Sterilization Technologies, Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK.
Luisa GregoriDivision of Emerging Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA. Luisa.gregori@fda.hhs.gov.
Chintamani AtreyaDivision of Blood Components and Devices, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, 20993, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogen reduction technologies using chemicals and or UV light have been demonstrated to improve the safety of ex vivo platelets from infectious diseases. However, UV light exposure also may affect the treated products, depending on wavelength and exposure. Alternatively, visible spectra 405 nm violet-blue light has broad-spectrum microbicidal activity. Here we tested the effect of 405 nm light on Treponema pallidum, the bacterium that causes syphilis. We contaminated platelets stored in plasma with two treponemal concentrations (low and high titers) and treated an aliquot with 270 J/cm

Indexed as

Blood PlateletsLightSyphilisTreponema pallidumAnimalsHumansRabbitsBacterial inactivationRabbitSyphilisTreponema pallidumViolet-blue light

Identifiers

PMID40481024
PMCPMC12144293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.