ArticleNature communications2025
Rewired m6A of promoter antisense RNAs in Alzheimer's disease regulates neuronal genes in 3D nucleome.
Abstract read
In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- mNature reviews. Neuroscience · 2026Review
- The crosstalk between RNA m6A modification and protein lactylation: emerging insights into tumor progression.Oncogene · 2026Review
- Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting mScience advances · 2026Article
- Research progress of blood-brain barrier penetrating and brain diseases therapy by natural biopolymer - based nanomedicine delivery systems.Materials today. Bio · 2026Review
- m6A RNA methylation in neural plasticity, brain aging, and neurodegenerative vulnerability.Molecular brain · 2026Review
- FTO-dependent mInflammation · 2026Article
- Inhibition of N6-Methyladenosine Accumulation by Targeting METTL3 Mitigates Tau Pathology and Cognitive Decline in Alzheimer's Disease.Research square · 2025Article
Corrections and comments
- Update of
Authors and funding
16 authors.
Benxia Hu *Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Yuqiang Shi *Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Feng XiongDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Yi-Ting ChenDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Xiaoyu ZhuDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Elisa CarrilloDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Xingzhao WenProgram in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA, USA.
Nathan DroletDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Chetan Singh RajpurohitHuffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
Xiangmin XuDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-5828-1533
Dung-Fang LeeThe University of Texas MD Anderson Cancer Center and UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA.ORCID http://orcid.org/0000-0003-2387-597X
Claudio SotoThe University of Texas MD Anderson Cancer Center and UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3412-0524
Sheng ZhongProgram in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA, USA.
Vasanthi JayaramanDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-2686-7310
Hui ZhengHuffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5427-3798
Wenbo LiDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA. Wenbo.li@uth.tmc.edu.ORCID http://orcid.org/0000-0002-9042-5664
Funding
Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CLAUDIO SOTO · 2008 to 2026
$36.1MThe second phase of NIH Common Fund 4D Nucleome Network Organizational HubU01CA200147 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2015 to 2024
$22.0MTMEM106b as a lysosomal adaptor to influence brain aging and tau pathogenesisP01AG066606 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LI, FENG · 2021 to 2025
$13.5MDynamics Of Ligand Gated Ion ChannelsR35GM122528 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Vasanthi Jayaraman · 2017 to 2026
$6.2MExtremely high-throughput mapping of protein, RNA, and chromatin interactions in health and diseaseDP1DK126138 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2020 to 2024
$3.7MSingle-Cell Analysis of Aging-Associated 4D Nucleome in the Human HippocampusU01DA052769 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI REN, BING, XU, XIANGMIN · 2020 to 2024
$3.4MSingle Cell Tracking of 3D Epigenetic Landscape Evolution During Embryonic DevelopmentR01HD107206 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yingxiao Wang, Sheng Zhong · 2022 to 2026
$3.2MBeyond Gene Dosage: Understanding Down Syndrome via 4D Genome OrganizationU01HL156059 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LI, WENBO · 2020 to 2024
$3.1MEnhancer RNAs in brain gene regulation and Alzheimer's diseaseR01AG082132 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Wenbo Li · 2023 to 2026
$3.0MGenetic dissection of Cardiac Conduction System homeostasis and RepairR01HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jun Wang · 2020 to 2026
$3.0MRole of circulating Abeta seeds and peripheral tissue damage in Alzheimer's disease pathogenesisRF1AG059321 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MORALES, RODRIGO, SOTO, CLAUDIO · 2020 to 2020
$2.9MKnockin mouse models of Alzheimer's DiseaseRF1AG020670 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ZHENG, HUI · 2022 to 2022
$2.3MNCI NIH HHS R01 CA246130NCI NIH HHS U01 CA200147NHLBI NIH HHS R01 HL142704NHLBI NIH HHS U01 HL156059NIAID NIH HHS P01 AI077774NIA NIH HHS P01 AG066606NIA NIH HHS R01 AG082132NIA NIH HHS RF1 AG020670NIA NIH HHS RF1 AG059321NICHD NIH HHS R01 HD107206NIDA NIH HHS U01 DA052769NIDDK NIH HHS DP1 DK126138NIGMS NIH HHS R01 GM136922NIGMS NIH HHS R01 GM138852NIGMS NIH HHS R35 GM122528NINDS NIH HHS R01 NS127922NINDS NIH HHS RF1 NS093652U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) U01HL156059U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM136922U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM122528U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG082132Welch Foundation AU-2000-20220331
Abstract
N
Indexed as
AdenosineAlzheimer DiseaseNeuronsPromoter Regions, GeneticRNA, AntisenseAgedBrainFemaleGene Expression RegulationHumansInduced Pluripotent Stem CellsMaleRNA, Messengertau ProteinsAdenosineMAPT protein, humanN-methyladenosineRNA, AntisenseRNA, Messengertau Proteins
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.