Evidence map›Paper›PMID 40480929›Full record

ArticleTrends in neurosciences2025

The ABCs of lipid exposure in maintaining neural health.

Akhila Rajan, Alex C Keene

Abstract read
In one paragraph

Article in Trends in neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Akhila RajanBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. Electronic address: akhila@fredhutch.org.
Alex C KeeneDepartment of Biology, Texas A&M university, College Station, TX, USA. Electronic address: akeene@bio.tamu.edu.

Funding

Investigating How Cellular Mechanisms Interface To Maintain Energy BalanceR35GM124593 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Akhila Rajan · 2017 to 2026
$4.5M
Circuit level analysis of sleep-metabolism interactionsR01NS131628 · NINDS · TEXAS A&M UNIVERSITY · PI JOSHUA T DUBNAU, Alex C Keene · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM124593NINDS NIH HHS R01 NS131628
6 · The paper itself

Abstract

ABC transporters modulate lipid homeostasis and are implicated in neurodegenerative diseases. In a recent study, Chen et al. uncovered unexpected dual roles for the Drosophila ABCA protein eater of debris (Eato), which suppresses phospholipid exposure in both neurons and phagocytes, conferring opposite functional outcomes in each cell type. This challenges classical models of ATP-binding cassette (ABC) transporter function and reveals new mechanisms by which lipid signaling regulates neuron-glia interactions in neurodegenerative contexts.

Indexed as

ATP-Binding Cassette TransportersDrosophila ProteinsLipid MetabolismNeuronsAnimalsDrosophilaHumansNeurodegenerative DiseasesNeurogliaATP-Binding Cassette TransportersDrosophila ProteinsABC transporterslipoproteinsneurodegenerationneuron-glia interactionsWallerian degeneration

Identifiers

PMID40480929
PMCPMC12240697

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.